by Karolinska Institutet Low levels of TAp73 correlate with an inflammatory signature and increased activity of the NF-κB pathway in breast cancer. (A) A flowchart of TCGA breast cancer data set analysis. (B) A heatmap based on differential gene set analysis comparing TAp73 low versus TAp73 high expressing samples (FC[Log2]>1, FDR > 0.05). (C) A volcano...
UNIVERSITY HEALTH NETWORK IMAGE: PRINCESS MARGARET SENIOR SCIENTIST DR. DANIEL DE CARVALHO AND TEAM TRANSFORMED IMMUNE KILLER T-CELLS INTO “SUPER SOLDIERS ” BY BOOSTING THEIR ABILITY TO KILL CANCER CELLS. CREDIT: UHN STRIDE TEAM Creating “super soldiers” of specific white blood cells to boost an anti-tumour response has been shown in a series of elegant...
by Memorial Sloan Kettering Cancer Center Credit: CC0 Public Domain Cancer cells and immune cells share something in common: They both love sugar. Sugar is an important nutrient. All cells use sugar as a vital source of energy and building blocks. For immune cells, gobbling up sugar is a good thing, since it means getting enough nutrients to grow...
by Washington University School of Medicine HIV-1 Virus. Credit: J Roberto Trujillo/Wikipedia Treatment for HIV has improved tremendously over the past 30 years; once a death sentence, the disease is now a manageable lifelong condition in many parts of the world. Life expectancy is about the same as that of individuals without HIV, though patients must...
by H. Lee Moffitt Cancer Center & Research Institute Intermediate magnification micrograph of a low malignant potential (LMP) mucinous ovarian tumour. H&E stain. The micrograph shows: Simple mucinous epithelium (right) and mucinous epithelium that pseudo-stratifies (left – diagnostic of a LMP tumour). Epithelium in a frond-like architecture is seen at the top of image. Credit: Nephron /Wikipedia. CC...
Macrophages – immune cells that both fight infections and fix the damage they cause – are often placed into two categories: those that increase inflammation (known as “M1”) to attack, and those that decrease inflammation to begin the healing process (“M2”). Researchers in the lab of Kathryn Miller-Jensen, associate professor of biomedical engineering and molecular,...
Special immune cells found in the brain, microglia, play a key role in the processes that make you feel uneasy and depressed in correlation with inflammation. The findings from a new study on mice suggest that microglial cells contribute to the negative mood experienced during several neurological diseases. Image credit: Pixabay (Free Pixabay license) David...
by Medical College of Georgia at Augusta University Drs. Babak Baban (foreground) and Krishnan Dhandapani. Credit: Kim Ratliff, Augusta University photographer Immediately after a traumatic brain injury and as long as one year later, there are increased levels of immune cells called ILCs in the brain promoting inflammation, which can worsen brain damage, scientists report. They...
by Max Delbrück Center for Molecular Medicine Previously only suspected, now made it visible thanks to the molecular reporter: where human tumor cells and brain cells of a mouse meet, the tumor cells have a different identity than everywhere else (green). Credit: Gargiulo Lab, MDC Glioblastoma is the most common malignant brain tumor in adults. Roughly...
by The Francis Crick Institute Dendritic cells are white blood cells that get their name from their tree-like shape. Credit: The Francis Crick Institute Researchers at the Francis Crick Institute have uncovered an important process in how our immune system detects signs of disease and activates a protective response. This understanding could improve efforts to find new...
