Tag: <span>Immune cells</span>

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Driving immunometabolism to control lung infection
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Driving immunometabolism to control lung infection

by Ciara O’shea, Trinity College Dublin When drugs to kill microbes are ineffective, host-directed therapy uses the body’s own immune system to deal with the infection. This approach is being tested in patients with COVID-19, and now a team of researchers at Trinity College Dublin has published a study showing how it might also work...

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New role for white blood cells in the developing brain

VIB (THE FLANDERS INSTITUTE FOR BIOTECHNOLOGY) Whether white blood cells can be found in the brain has been controversial, and what they might be doing used to be complete mystery. In a seminal study published in Cell, an international team of scientists led by Prof. Adrian Liston (VIB-KU Leuven, Belgium & Babraham Institute, UK) describe...

India clears a psoriasis drug for COVID-19, and a tiny US biotech’s shares soar
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India clears a psoriasis drug for COVID-19, and a tiny US biotech’s shares soar

Dive Brief: India’s drug regulator has granted an emergency approval to the antibody drug itolizumab to treat the potentially deadly immune response, cytokine release syndrome, that appears to affect some patients hospitalized with acute respiratory distress related to COVID-19. The Drugs Controller General of India cleared the treatment for use after itolizumab, alongside standard of...

Mapping the immune landscape of hematological cancers may help to enhance therapies
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Mapping the immune landscape of hematological cancers may help to enhance therapies

by University of Helsinki Activating the immune system is a promising form of cancer treatment. Researchers at the University of Helsinki and Helsinki University Hospital as well as the University of Eastern Finland mapped out the immune landscape of hematological malignancies in a dataset covering more than 10,000 patients to identify drug targets and patient...

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Engineered killer immune cells target tumours and their immunosuppressive allies

Natural killer immune cells engineered to target the PD-L1 molecule can directly kill tumour cells in mice and reduce the numbers of immunosuppressive cells harbouring PD-L1 in mice and humans Scientists have engineered natural killer immune cells that not only kill head and neck tumour cells in mice but also reduce the immune-suppressing myeloid cells...

A key gene modifies regulatory T cells to fine-tune the immune response
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A key gene modifies regulatory T cells to fine-tune the immune response

by Salk Institute A histology image showing inflammation in colon epithelium. Weakening of regulatory T cell function induces infiltration of immune cells (small blue dots) into colon epithelium (blue layer) and causes colitis. Credit: Salk Institute The human immune system is a finely-tuned machine, balancing when to release a cellular army to deal with pathogens,...

To let neurons talk, immune cells clear paths through brain’s ‘scaffolding’
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To let neurons talk, immune cells clear paths through brain’s ‘scaffolding’

by University of California, San Francisco To make new memories, our brain cells first must find one another. Small protrusions that bud out from the ends of neurons’ long, branching tentacles dock neurons together so they can talk. These ports of cellular chatter—called synapses, and found in the trillions throughout the brain—allow us to represent...

Smart structures: Structural cells of the body control immune function
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Smart structures: Structural cells of the body control immune function

by Austrian Academy of Sciences Schematic outline of the study, which used genomic assays (RNA-seq, ATAC-seq, ChIPmentation, flow cytometry) to investigate epigenetic and transcription regulation in structural cells (endothelium, epithelium and fibroblast) from twelve mouse organs. Credit: Thomas Krausgruber / CeMM In a Nature paper, CeMM researchers report on the epigenetic and transcriptional regulation in...