by American Society for Biochemistry and Molecular Biology Researchers engineered immune cells (NK-92) to anchor glycocalyx-editing (GE) enzymes on the surface. The modified immune cells were able to break through the glycocalyx armor of cancer cells. Credit: Sangwoo Park, Cornell University One of the ways that cancer cells hide from the body’s immune system is...
by Krista Conger, Stanford University MYC regulated St6galnac4 promotes display of the glycan disialyl-T. (A) Murine T-ALL cell surface sialic acids were quantified at various time points after doxycycline administration to turn off expression of the MYC transgene. Sialic acids were detected via oxidation with mild periodate treatment and subsequent labeling with an aminooxy-biotin probe...
by Instituto de Medicina Molecular Credit: Pixabay/CC0 Public Domain Muscle is able to regenerate through a process that involves multiple steps and players, including the immune system. As our organism ages, the muscles lose the capacity to regenerate. Now, a new study led by Joana Neves and Pedro Sousa-Victor, group leaders at the Instituto de...
by Krista Weidner, Pennsylvania State University Credit: Unsplash/CC0 Public Domain Vitamin D plays an integral role in regulating immune function, and Penn State researchers have identified immune cells in mice that can be differentiated by whether or not they have vitamin D receptors—a finding that could lead to a better understanding of the link between vitamin D...
by Alan Dove, Columbia University Irving Medical Center Combination of CXCL16 and CCL20 synergizes to promote antitumor immunity. (A) Schematic overview of the approach to recruit DCs to tumors via CCL20 production in probiotic bacteria to complement activated T cell recruitment via CXCL16 (B) Tumor growth curves from C57BL/6 mice (n = 5 per group) subcutaneously implanted...
by Leibniz-Institut für Lebensmittel-Systembiologie an der TU München Whether as a medicinal plant or foodstuff, ginger is also becoming increasingly popular in Germany. Credit: Gisela Olias/Gaby Andersen/Leibniz-LSB@TUM Ginger has a reputation for stimulating the immune system. New results from the Leibniz Institute for Food Systems Biology at the Technical University of Munich (Leibniz-LSB@TUM) now support...
by Washington University School of Medicine CD5+ DC frequency was reduced in tumor-affected lymph nodes, and their presence correlated with greater patient survival in multiple tumors. CD5+ DC numbers increased during ICB therapy, and low IL-6 concentrations promoted their de novo differentiation. The requirement for CD5 on DCs was linked to the priming of effector CD5hiT cells and...
by Monash University Graphical abstract. Credit: Immunity (2023). DOI: 10.1016/j.immuni.2023.01.016 Melbourne researchers have improved our understanding of how the immune system is regulated to prevent disease, identifying a previously unknown role of ‘natural killer’ (NK) immune cells. The Monash University-led study identified a new group of immune cells, known as tissue-resident memory natural killer (NKRM) cells. NKRM cells limited immune...
by Leiden University Tumor-infiltrating Vδ1 and Vδ3 T cell subsets display hallmarks of cytotoxic activity in MMR-d colon cancers. a, UMAP embedding showing the clustering of γδ T cells (n = 4,442) isolated from MMR-d colon cancers (n = 5) analyzed using scRNA-seq. The colors represent the TCR Vδ chain usage. Dots represent single cells. b, The frequencies of...
LEIBNIZ INSTITUTE FOR NATURAL PRODUCT RESEARCH AND INFECTION BIOLOGY – HANS KNOELL INSTITUTE IMAGE: A CYTOKINE (BLUE) SECRETED BY T CELLS (RED) STIMULATES MONOCYTES (BACKGROUND) TO FEED ON C. ALBICANS HYPHAE (YELLOW). CREDIT: LUO YU/LEIBNIZ-HKI Certain T cells can secrete cytokines that are normally part of the innate immune system, as researchers from the Leibniz Institute for...
