by Ekaterina Pesheva, Harvard Medical School New research shows thymus cells assume various identities to teach nascent T cells how to distinguish friend from foe. Credit: Daniel Michelson, Mathis/Benoist Lab, Harvard Medical School The human immune system is a nearly perfect defense mechanism. It protects the body from disease-causing bacteria, viruses, and other pathogens. It detects...
by Cedars-Sinai Medical Center Graphical abstract. Credit: Cell Reports (2022). DOI: 10.1016/j.celrep.2022.110977 Investigators from Cedars-Sinai Cancer have discovered that cancerous tumors called soft-tissue sarcomas produce a protein that switches immune cells from tumor-attacking to tumor-promoting. The study, published today in Cell Reports, could lead to improved treatments for soft-tissue sarcomas. The researchers focused on the tumor microenvironment—an ecosystem...
Interview conducted by Danielle Ellis, B.Sc.May 30 2022 Thought LeadersDr. Chenqu Suo and Dr. Cecilia Domínguez Conde Clinical PhD Student and Postdoctoral FellowWellcome Sanger Institute In this interview, News-Medical speaks to two researchers each discussing their respective studies that have contributed to the Human Cell Atlas; Dr. Chenqu Suo from the Wellcome Sanger Institute, co-first author of the...
by Case Western Reserve University Illustration depicting a macrophage dyed using a Giemsa stain. Credit: Noah Smith/Wikimedia Commons, CC BY-SA 4.0 Cancer researchers at Case Western Reserve University School of Medicine say they have successfully suppressed the growth of some solid tumors in research models by manipulating immune cells known as macrophages. The researchers say this discovery...
by Weill Cornell Medical College Microglial NF-kB accelerates the seeding and spread of tau aggregates in the cortex of mice inoculated with tau seeds. Depleting microglia (top right) or inhibiting microglia NF-kB (bottom right) diminished the amount of tau aggregates. (Controls are shown on the left.). Credit: Dr. Li Gan Inhibiting an important signaling pathway...
By JOE DAVIES HEALTH REPORTER FOR MAILONLINE PUBLISHED: 13:32 EDT, 14 April 2022 | UPDATED: 13:42 EDT, 14 April 2022 Immune cells against glandular fever may hold the key to treating multiple sclerosis, scientists have claimed. In a small trial, patients with MS were implanted with T-cells that target the virus that causes glandular fever. Brain scans suggested the progression...
by Walter and Eliza Hall Institute of Medical Research Comparable early LCMV titres in WT control and Casp8ΔFoxp3 mice. (A) Summary of autoimmune infiltration in pancreas (Panc), salivary gland (SG), kidney (Kid), liver, lung and intestine (Int) of LCMV-infected Casp8ΔFoxp3 (C8ΔFoxp3) mice that succumbed (sick) or survived (survivor) until the end of the 139 day...
MIT biological engineers have developed a simple way to identify B or T cells that interact with viral or bacterial proteins. The human body has millions of unique B and T cells that roam the body, looking for microbial invaders. These immune cells’ ability to recognize harmful microbes is critical to successfully fighting infection. MIT biological engineers...
by Dresden University of Technology Real-time deformability cytometry and subsequent AI-based classification of blood cells. Credit: Andreas Walther, CC BY-NC 4.0 Loss of interest, joylessness, lack of drive and increased fatigability—all these complaints are among the main symptoms of depression, a mental illness affecting an estimated 5% of the population in Germany. Pathophysiological features of...
by International Society for Stem Cell Research Monkey iPSCs with edited CCR5 locus growing in culture. Credit: Saritha D’Souza, Wisconsin National Primate Research Center, USA Genetic engineering can make immune cells resistant to infection with human or monkey (simian) immunodeficiency virus (HIV and SIV, respectively). Recently, treatment with HIV-resistant immune cells has given encouraging results...
