by Cold Spring Harbor Laboratory In this image of the mouse brain, immune cells known as microglia (white) are seen interacting with other brain cells called chandelier cells (red) and pyramidal neurons (blue). This interaction helps pyramidal neurons grow the right connections during development. Credit: Nicholas Gallo/Van Aelst lab/CSHL, 2022 Microglia, the immune cells of...
by Agency for Science, Technology and Research (A*STAR), Singapore Fig. 1: Histone acetylome-wide association study of TB. Credit: DOI: 10.1038/s41564-021-01049-w A study led by the Agency for Science, Technology and Research’s (A*STAR) Genome Institute of Singapore (GIS) and Infectious Diseases Labs (ID Labs) has identified a gene, KCNJ15, that is associated with helping our immune...
by University of Helsinki The figure shows immunostaining of lymphoma tissue rich in checkpoint proteins expressing macrophages. Credit: University of Helsinki Approximately 700 people are diagnosed with diffuse large B-cell lymphoma (DLBCL) in Finland each year. It is the most common cancer that originates from lymphocytes, immune system cells. Although the disease is treated with...
UNIVERSITY OF CALIFORNIA SAN FRANCISCO MEDICAL CENTER Using data from over 100,000 malignant and non-malignant cells from 15 human brain metastases, UCSF researchers have revealed two functional archetypes of metastatic cells across 7 different types of brain tumors, each containing both immune and non-immune cell types. Their findings, published the February 17 issue of CELL,...
by National Institutes of Health Workflow for prospective identification of anti-tumor, neoantigen-specific TCRs using NeoTCR signature. Based on single cell gene signature scoring of TIL clusters, we first identify candidate NeoTCR4 and NeoTCR8 cluster populations. Dominant and subdominant clonotypes within the the two candidate NeoTCR clusters are reconstructed and tested against autologous patient tumor mutations,...
Cornell researchers have for the first time successfully imaged the entire depth of the lymph nodes in a living mouse using three-photon microscopy. The breakthrough technique’s micrometer clarity and noninvasive nature allowed the team to observe the dynamic interactions of immune cells in real time and in an environment that is notoriously dense and difficult...
by University of California, San Francisco Cerebal vascular imaging. Credit: © Michel Royon / Wikimedia Commons, CC BY-SA 3.0 In work that will enhance the study of such diseases as stroke and dementia, researchers at UC San Francisco have cataloged all the cells that form the blood vessels of the human brain, along with their locations...
Heidi Ledford T cells (seen in this scanning electron microscope image) from people who have been vaccinated or recovered from COVID-19 can recognize and target the Omicron variant.Credit: Steve Gschmeissner/SPL When immunologists Wendy Burgers and Catherine Riou heard about the Omicron coronavirus variant last November, they knew they would need to find the answers to...
by Ludwig Maximilian University of Munich Credit: CC0 Public Domain CD4+ T cells are important parts of the immune system and play a key role in defending the body against pathogens. As they possess a great variety of defense mechanisms against HIV in their resting state, they are infected only very rarely—but these few infected...
by University of Melbourne Retinal microglia associate with vasculature and neuronal synapses. (A) Whole-mounted mouse retina (Cx3cr1GFP/+) was labeled with anti-EGFP (microglia, green), and G. simplicifolia IB4 (blood vessels, red). The highlighted region shows microglial association with vessels within the superficial vascular plexus (Inset). (Scale bars, 500 µm; 50 µm, Inset.) (B) The association of...
