by Walter and Eliza Hall Institute WEHI researcher Dr Michael Chopin have made a surprise discovery about how immune ‘sentinel’ cells are maintained, which could have implications for drugs in development for treating cancer. Credit: WEHI WEHI researchers have made a surprise discovery about how immune ‘sentinel’ cells are maintained, which could have implications for drugs in development...
by Ludwig Maximilian University of Munich Immunfluorescence of mononuclear phagocytes in the murine kidney. Credit: Barbara Schraml, Stephan Rambichler; LMU The immune system is highly complex. For example, a particular class of cells called mononuclear phagocytes (MNPs) plays important roles in the uptake and disposal of damaged cells, the elimination of invasive pathogens and other foreign...
by Amy Mone, Johns Hopkins University A tumor-specific T cell engages with a tumor cell. Bystander T cells do not engage with the tumor. Credit: PNAS Dec. 10, 2002, Copyright (2002) National Academy of Sciences Cancer-fighting immune cells in patients with lung cancer whose tumors do not respond to immunotherapies appear to be running on a different “program”...
by University of Würzburg Liver tissue with innate lymphoid cells (ILCs), visualised here as red dots. Credit: Ye Ouyang / University of Wuerzburg When pathogens invade the human body, a rapid response is required. At the forefront of the immune response are special immune cells. They reside in various tissues such as the lungs, liver, skin...
by Stuart Wolpert and Todd Schindler, University of California, Los Angeles In this image from a microscopy video, scientists track the activity of NFκB inside the cell as it responds to a stimulus. Credit: Brooks Taylor/UCLA The body’s immune cells naturally fight off viral and bacterial microbes and other invaders, but they can also be reprogrammed...
by Karolinska Institutet Credit: Pixabay/CC0 Public Domain Researchers at Karolinska Institutet in Sweden have analyzed and described in detail the immune cells residing in the human bile duct. The findings may pave the way for new treatment strategies against disorders of the bile duct, which are often linked to immunological processes. The study is published in the...
by Max Planck Society Neutrophils (green) form cell swarms and accumulate at tissue sites where they need to contain damaged cells or invading microbes. Multicolored trajectories of neutrophil migration paths are displayed. Credit: MPI of Immunobiology & Epigenetics/ T. Lämmermann Neutrophils belong to the first responders of our immune system. They circulate in our bodies and...
by German Cancer Research Center Glioma of the left parietal lobe. CT scan with contrast enhancement. Credit: Mikhail Kalinin/CC BY-SA 3.0 Brain tumor cells with a certain common mutation reprogram invading immune cells. This leads to the paralysis of the body’s immune defense against the tumor in the brain. Researchers from Heidelberg, Mannheim and Freiburg discovered this mechanism, and at...
by Ludwig Institute for Cancer Research Credit: CC0 Public Domain A Ludwig Cancer Research study has discovered how to revive a powerful but functionally inert subset of anti-cancer immune cells that are often found within tumors for cancer therapy. Led by Ludwig Lausanne’s Ping-Chih Ho and Li Tang of the École Polytechnique Fédérale de Lausanne, the study describes how...
The study shows that a diet high in sugar and fat causes damage to Paneth cells, immune cells in the gut that help keep inflammation in check. When Paneth cells aren’t functioning properly, the gut immune system is excessively prone to inflammation, putting people at risk of inflammatory bowel disease and undermining effective control of disease-causing microbes....
