Mice who have been tricked into thinking they are fasting manage inflammation more easily, according to neurobiologists at The University of Manchester and collaborators from the University of Naples ‘Federico II, in Italy. The study of mice and published in Current Biology is also the first to show that the well-established protective effects of fasting...
Tag: <span>inflammation</span>
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Long-term study supports link between inflammation and cognitive problems in older breast cancer survivors
by University of California, Los Angeles Credit: Pixabay/CC0 Public Domain Scientists are still trying to understand why many breast cancer survivors experience troubling cognitive problems for years after treatment. Inflammation is one possible culprit. A new long-term study of older breast cancer survivors published today in the Journal of Clinical Oncologyand co-led by UCLA researchers adds important...
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Consuming green vegetables, supplements suppresses inflammatory bowel disease
by American Physiological Society Credit: CC0 Public Domain The dietary supplement chlorophyllin alleviates inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, according to researchers from the Center for Diabetes and Metabolism Research at Sichuan University in China and from Cedars Sinai Medical Center in Los Angeles. In addition, chlorophyllin significantly reduces mortality related to...
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Inflammatory signaling linked to leukemia progression
by Kevin McCullough, Northwestern University Loss of IL-6 rescues multi-organ leukemia infiltrations in DKO mice. (A) Microarray gene expression data of bone marrow CD34+ cells from 47 MDS patients. Housekeeping genes GAPDH and ACTB were plotted to demonstrate the modest raw intensity without normalization. TNNT2 and CD34 were plotted as negative and positive controls, respectively. Data...
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Down on Vitamin D? It could be the cause of chronic inflammation
by University of South Australia There’s a direct link between low levels of vitamin D and high levels of inflammation. Credit: Rebecca Wood Inflammation is an essential part of the body’s healing process. But when it persists, it can contribute to a wide range of complex diseases including type 2 diabetes, heart disease, and autoimmune...
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Hydrogen generated by Si-based agent attenuates inflammation in ulcerative colitis mouse model
by Osaka University Fig. 1. Amount of hydrogen generated per 1 g of the mouse gastrointestinal tract in the control group compared with in the mice given the silicon (Si)-based agent. Credit: Scientific Reports (2022). DOI: 10.1038/s41598-022-13655-7 Many people worldwide suffer from a chronic type of inflammatory bowel disease (IBD) called ulcerative colitis (UC), which is characterized by...
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Finding the triggers of inflammation
by Hudson Institute of Medical Research TLR-induced inflammasome priming triggers IL-1β and NLRP3 ubiquitylation. a BMDMs were primed with Lipopolysaccharide (LPS, 50 ng/ml) for up to 8 h (hr) and ubiquitylated (Ub.) proteins were isolated from cell lysates by Tandem Ubiquitin Binding Entity (TUBE) purification. Immunoblots were performed on cell lysates (input) and purified ubiquitylated proteins (TUBEs) for the...
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Enzymes linked with immune cell activity could hold key to better understanding inflammation
by Adrianna MacPherson, University of Alberta Credit: CC0 Public Domain New research shows a group of enzymes may have a critical role in the process of how immune cells are activated and then migrate to certain sites in the body—findings that could improve our understanding of inflammation and potentially lead to new treatments. In a...
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Nerve stimulation promotes resolution of inflammation
KAROLINSKA INSTITUTET The nervous system is known to communicate with the immune system and regulate inflammation in the body. Researchers at Karolinska Institutet in Sweden now show how electrical activation of a specific nerve can promote healing in acute inflammation. The finding, which is published in the journal PNAS, opens new ways to accelerate resolution of...
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‘Growing end’ of inflammation discovered
by University of Bonn Image of the junction between the danger sensor NLRP3 and its signal protein, shown in magnification with the calculated protein structure. Credit: Inga V. Hochheiser Redness, swelling and pain are signs of inflammation. It serves to protect the body from pathogens and foreign substances. Researchers from the Universities of Bonn and...