By Jason Mast May 11, 2022 ADOBE For two decades, Luda Diatchenko investigated the underlying biology of pain like a detective chasing clue after clue: What role does this gene play? How about that protein? She always wondered, though, what she would find if she could look at how every gene inside a cell behaves...
UNIVERSITAT AUTONOMA DE BARCELONA A team led by the Institut de Neurociències at the Universitat Autònoma de Barcelona (INc-UAB) managed to reduce chronic inflammation associated with multiple sclerosis in mice thanks to the administration of a type of lipid that mediates inflammation. The team found that these types of mediator substances, responsible for resolving the...
by Michael Morrison, Massachusetts General Hospital Acetylcholine is produced by bone marrow B lymphocytes. Credit: Nature Immunology (2022). DOI: 10.1038/s41590-022-01165-7 The immune system’s white blood cells, which are produced in the bone marrow, mostly help to defend against bacteria and injury, but sometimes they can turn against the body—for example, in cardiovascular disease, their inflammatory aggression can...
by Kathy Keatley Garvey, UC Davis A control burn at the University of California, Davis. Credit: Kathy Keatley Garvey Every year some 10,000 burn victims in the United States undergo an acute inflammatory reaction and die of burn-related infections, according to the Centers for Disease Control and Prevention. Now a newly published study by a...
by Trinity College Dublin Credit: Pixabay/CC0 Public Domain Irish and German scientists have just identified how specific immune cells can work together in fat to cause inflammation that leads to weight gain and obesity. Their work pinpoints new avenues to exploit the regulation of that inflammation in fat tissue, thereby suggesting new ways to manage...
by Dr Sophia Davidson, University of Melbourne Credit: CC0 Public Domain “How many people actually have this disease?” It’s a potentially triggering question at a family BBQ. I had just finished explaining why I’d recently traveled to the U.S. to work on samples from patients with a rare disease called proteasome related autoinflammatory syndrome (PRAAS)....
by Walter and Eliza Hall Institute of Medical Research Graphical abstract. Credit: DOI: 10.1016/j.immuni.2022.01.003 A WEHI-led study has identified a molecular ‘culprit’ responsible for causing damaging levels of cell death and inflammation in the body. The findings could lead to improved treatment options for a range of conditions driven by inflammatory cell death, including the...
by New York University In normal tissue, PAR2—seen here in fluorescent green—is found on the surface of cells, but in inflamed tissue, it moves from the surface of cells to compartments within cells called endosomes. Credit: Bunnett Lab, NYU Dentistry Researchers at the NYU Pain Research Center have identified a mechanism that underlies inflammation and...
by British Medical Journal Credit: Pixabay/CC0 Public Domain Living alone for several years and/or experiencing serial relationship break-ups are strongly linked to raised levels of inflammatory markers in the blood–but only in men–finds a large population study published online in the Journal of Epidemiology & Community Health. Although the inflammation was classified as low grade, it...
by Massachusetts General Hospital Credit: CC0 Public Domain High cholesterol and inflammation are key drivers of heart disease, and an inflamed buildup of lipids can cut off the blood supply through a coronary artery to cause a heart attack. Because white blood cells, which usually defend against infection, trigger inflammation in these situations, a team...
