First generation stem cell therapies have been demonstrated to reduce chronic inflammation, but are unreliable when it comes to producing other benefits. Since very few transplanted cells survive, it was thought that benefits are produced via signaling that changes the behavior of native cells. This has led to work on therapies that deliver extracellular vesicles released by stem cells rather than the...
by Sara Tiner, Mayo Clinic Credit: Unsplash/CC0 Public Domain Mayo Clinic researchers have linked the T cell dysfunction seen in rheumatoid arthritis with a metabolic deficiency, reported in a new Nature Immunology publication. In “helper” T cells from patients with rheumatoid arthritis, low levels of a specific amino acid lead to cellular miscommunication, but supplying it may provide...
IMAGE: PROFESSOR RAUL MENDEZ CREDIT: WORLDWIDE CANCER RESEARCH Researchers in Spain, funded by the UK charity Worldwide Cancer Research, have discovered a new drug target that could help protect against diet-induced obesity and its related health issues. The research, led by Professors Mercedes Fernandez and Raul Mendez, found that a protein called CPEB4 was present...
by Trinity College Dublin Credit: Unsplash/CC0 Public Domain Researchers at Trinity are providing fresh insights into joint inflammation in patients with rheumatoid arthritis (RA). The condition currently affects about 1 percent of the world’s population and about 2,000 new cases are diagnosed annually in Ireland. Patients suffering from RA require lifelong treatment and can experience...
This open access paper reviews the relationship between DNA damage and inflammation in the specialized environments that support stem cell populations. Aging produces many changes that lead to reduced stem cell function. Changes in the niche, the supporting cells that help to ensure stem cells retain their function, are of increasing interest to the research community. The chronic inflammation of aging is also an area...
by Bob Yirka , Medical Xpress The Samoan medicinal plant garden at the Scientific Research Organization of Samoa. Credit: Seeseei Molimau-Samasoni A team of researchers from Samoa, New Zealand and the U.S. has found that the leaves of the Samoan tree, matalafi, are as good at relieving inflammation as ibuprofen. In their paper published in Proceedings...
IMAGE: NEUTROPHIL EXTRACELLULAR TRAPS (NETS) CONTRIBUTE TO COVID-19, SEPSIS, ACUTE RESPIRATORY DISTRESS SYNDROME, AND OTHER INFLAMMATORY CONDITIONS. THIS IMAGE SHOWS MULTIPLE NETS; IN PINK ARE AREAS WHERE THE ENZYME HISTONE H3 IS CHEMICALLY MODIFIED, A KEY INITIATING STEP IN NET FORMATION. CREDIT: VALENTINA POLI AND MARCO DI GIOIA, ZANONI LAB, BOSTON CHILDREN’S HOSPITAL As we’ve...
by Emory University Credit: Pixabay/CC0 Public Domain In a paper published recently in Pharmacological Reviews, Emory University School of Medicine researchers outlined the impact of inflammation on motivation as it relates to depression. The researchers propose that low grade inflammation affects brain chemicals and brain circuits that regulate motivation, ultimately leading to motivational deficits and a loss of interest...
by Heriot-Watt University EPAC1 under the microscope. Credit: Heriot-Watt University Scientists are testing whether a new molecule could help switch off the inflammation that worsens cardiovascular diseases. The Heriot-Watt and University of Glasgow team is using real human blood vessel cells to test the molecule in the lab. Their focus is on finding using the molecule...
by University of Texas M. D. Anderson Cancer Center Pancreatic cancer cells (blue) growing as a sphere encased in membranes (red). Credit: National Cancer Institute A new discovery from researchers at The University of Texas MD Anderson Cancer Center has clarified the long-established connection between inflammation and pancreatic cancer development. According to the study published today in Science, pancreatic...
