by University of Barcelona Credit: Cell Communication and Signaling (2024). DOI: 10.1186/s12964-024-01972-5 Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high morbidity and mortality worldwide. In affected people, insulin is unable to facilitate the uptake of glucose through tissues and organs, leading to an increase in blood glucose...
Tag: <span>insulin resistance</span>
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High levels of adrenomedullin found to promote obesity-associated insulin resistance
by Justin Jackson , Medical Xpress Credit: Pixabay/CC0 Public Domain Adrenomedullin (ADM) inhibits endothelial insulin signaling, contributing to obesity-associated insulin resistance, according to research conducted by the Max Planck Institute for Heart and Lung Research in Germany. Findings suggest that elevated plasma levels of ADM impair insulin receptor function in endothelial cells, leading to reduced vascular insulin delivery and systemic insulin...
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Insulin degradation uncovered as a new driver of resistance
By Hugo Francisco de SouzaReviewed by Susha Cheriyedath, M.Sc.Dec 22 2024 New study identifies insulin ‘chain-splitting’ during bloodstream transit as a game-changer in understanding and treating diabetes and insulin resistance. Study: Chain splitting of insulin: an underlying mechanism of insulin resistance? Image Credit: Nastasiiaa / Shutterstock In a recent study published in the journal NPJ Metabolic Health and Disease, researchers hypothesize that...
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World’s most common heart valve disease linked to insulin resistance
by Taylor & Francis Credit: Unsplash/CC0 Public Domain A large population study of men over 45 indicates insulin resistance may be an important risk factor for the development of the world’s most common heart valve disease—aortic stenosis (AS). Published in the Annals of Medicine, the findings are believed to be the first to highlight this previously unrecognized...
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Insulin resistance caused by sympathetic nervous system over-activation, a paradigm-shifting study finds
by Justin Jackson , Medical Xpress Credit: Cell Metabolism (2024). DOI: 10.1016/j.cmet.2024.09.012 Rutgers Robert Wood Johnson Medical School and collaborating institutions have found that overnutrition leads to insulin resistance and metabolic disorders through increased activity of the sympathetic nervous system (SNS). The study shows that reducing SNS activity can prevent insulin resistance induced by a high-fat diet,...
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Insulin resistance is linked to over 30 diseases—and to early death in women, finds UK study
September 7, 2024 by Diabetologia Credit: Pixabay/CC0 Public Domain Insulin resistance is associated with 31 different diseases, and in women, is also linked to higher odds of early death. This is according to a study of data on hundreds of thousands of people in the UK being presented at the Annual Meeting of the European...
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Study finds increased body and abdominal fat cause insulin resistance in teenagers, raising type 2 diabetes risk
by University of Eastern Finland Both total body fat mass and abdominal fat cause hyperglycemia, hyperinsulinemia, and insulin resistance, with abdominal fat doubling the risk of metabolic dysfunction. However, light physical activity can significantly reduce total body fat mass and insulin resistance. Credit: Andrew AgbajeHigh fat mass in adolescence causes insulin resistance, which can lead to...
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Reversing insulin resistance in liver cells could treat type 2 diabetes
AMERICAN CHEMICAL SOCIETY Although diabetes is a common condition, no cure exists yet. Current therapies can manage blood sugar levels, but they do not address insulin resistance. But now, recent research reported in ACS Nano shows that targeting certain highly reactive molecules in the liver can reverse insulin resistance in human liver cells and diabetic...
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The Worst Dinner Foods That Increase Insulin Resistance And Slows Metabolism
Georgia Dodd Sat, March 25, 2023 at 3:30 PM MST· 3 min read We all know that there are certain foods you shouldn’t be eating in the morning for weight loss, but many don’t consider dinner’s impact. There are some foods that you may be eating that are slowing your metabolism and increasing insulin resistance. Specifically, Dr. Andrea...
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Arterial stiffness raises blood pressure in adolescents via insulin resistance
UNIVERSITY OF EASTERN FINLAND In the young population, arterial stiffness, an emerging risk factor for hypertension, indirectly raises blood pressure via an increase in insulin resistance but not via an increase in body fat, a paper published in Frontiers in Cardiovascular Medicine concludes. There is a global effort aimed at screening, identification, and early diagnosis of hypertension...
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