by Nathalie Huber, University of Zurich Images of skin from patient 1 after 10-month topical GDL treatment. Credit: Science Translational Medicine (2025). DOI: 10.1126/scitranslmed.adp4447 Systemic lupus erythematosus, or lupus, is a complex autoimmune disease in which the immune system mistakenly attacks healthy tissue, often affecting the skin, joints, kidneys and nervous system. Lupus symptoms include inflammation, skin rashes,...
Tag: <span>Lupus</span>
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Hydroxychloroquine Slows Progression of Cutaneous Lupus to SLE
Edited by Deepa Varma February 28, 2025 011 Add to Email Alerts TOPLINE: Early initiation of hydroxychloroquine (HCQ) in patients with cutaneous lupus erythematosus (CLE) reduces the risk for progression to systemic lupus erythematosus (SLE) by 87% over time. METHODOLOGY: TAKEAWAY: IN PRACTICE: “Our findings suggest that early initiation of HCQ in patients with CLE...
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Obinutuzumab efficacious for renal response in lupus nephritis
by Elana Gotkine For patients with active lupus nephritis, obinutuzumab, a humanized type II anti-CD20 monoclonal antibody plus standard therapy is more efficacious for providing a complete renal response than standard therapy alone, according to a study published online Feb. 7 in the New England Journal of Medicine. The research was published to coincide with the International Society of Nephrology...
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New study supports caution regarding use of steroids for patients with lupus
by Zachary Fulwood, Johns Hopkins University School of Medicine Credit: Unsplash/CC0 Public Domain A new study of more than 2,900 patients provides evidence that it’s likely best to use as little corticosteroid medicine as possible when treating people who have lupus pericarditis, a common heart complication of the autoimmune disease systemic lupus erythematosus (SLE). This study,...
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Drug can stave off organ damage from lupus, research reveals
by Dennis Thompson Lupus can do irreversible harm to a person’s organs, damaging the lungs, kidneys, heart, liver and other vital organs through inflammation. ADVERTISING But a newer lupus drug appears to protect patients from much of this organ damage, a new study suggests. Anifrolumab (brand name Saphnelo) reduced the risk of long-term organ damage progression...
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How gut bacteria might trigger autoimmune diseases like lupus
by Mallory Locklear, Yale University Introduction of E. gallinarum into a complex microbiota leads to systemic translocation and induction of autoantibodies. Credit: Science Translational Medicine (2025). DOI: 10.1126/scitranslmed.adj6294 Bacteria in the gut have been implicated in autoimmune diseases, like lupus, that don’t primarily affect the gastrointestinal system. But how those bacteria affect the human immune system remains unclear....
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Topical mupirocin lowers lupus inflammation, study finds
by Valerie Goodwin, University of Michigan Credit: Yaroslav Shuraev from Pexels Systemic lupus erythematosus, more commonly known as lupus, has a variety of symptoms and room for improvement when it comes to treatment. Cutaneous lupus erythematosus is a common manifestation of systemic lupus erythematosus. The condition is characterized by rashes on various parts of the body...
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Organ Damage More Common in Early Stages of Lupus
MEDBRIEF Edited by Manasi Talwadekar August 12, 2024 TOPLINE:The first year after the diagnosis of systemic lupus erythematosus (SLE) is crucial, with the highest percentage of patients experiencing organ damage. Cardiovascular issues are the second most prevalent after musculoskeletal damage in both early and later stages of SLE. METHODOLOGY:Researchers assessed organ damage persisting at least...
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Horrifying video shows in detail what mysterious disease that hit Lady Gaga and Selena Gomez does to the body
By Rebecca Whittaker For Mailonline Published: 06:36 EDT, 12 August 2024 | Updated: 08:11 EDT, 12 August 2024 A horrifying video of a woman whose heart and lungs stopped working shows the stark reality of lupus, the incurable disease that hit Selena Gomez and Lady Gaga. Melisa Woolery, 31, was diagnosed with the incurable condition...
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Studies discover single-gene mutation that can cause lupus
By Paul McClure Researchers have pinpointed a genetic mutation that can lead to lupusDepositphotos In two separate studies, German researchers have identified the single-gene mutation that can lead to the incurable autoimmune disease lupus. The discovery opens the door to developing new therapeutic approaches and testing for the mutation, which would ensure early diagnosis of the...