by The Scripps Research Institute Chemoproteomic discovery of SLC15A4 inhibitors. Credit: Nature Chemical Biology (2024). DOI: 10.1038/s41589-023-01527-8Scientists from Scripps Research have developed a small molecule that blocks the activity of a protein linked to autoimmune diseases, including systemic lupus erythematosus (SLE) and Crohn’s disease. This protein, known as SLC15A4, has been considered largely “undruggable,” as most...
Autoimmune patients in CAR-T study see striking improvements across lupus and other diseasesLei Lei WuNews ReporterSAN DIEGO — All of the first 15 autoimmune disease patients who received CAR-T therapy at a German hospital saw the debilitating symptoms of their diseases, including lupus and myositis, substantially improve or go away entirely, according to new research...
by American College of Rheumatology Credit: CC0 Public Domain New research at ACR Convergence 2023, the American College of Rheumatology’s annual meeting, demonstrates that CAR-T cell therapy could lead to sustained suppression of autoantibodies in treatment-resistant lupus while maintaining a robust response to vaccines. Systemic lupus erythematosus (SLE, lupus) is a complex autoimmune disease marked by...
By Sarah Moore Reviewed by Danielle Ellis, B.Sc. Comorbidities are common in people with lupus. The autoimmune disease increases the risk of complications such as cardiovascular disease, cancer, and even mental health illnesses. Here, we explore some of the most common comorbidities in lupus. Image Credit: SewCreamStudio/Shutterstock.com Lupus and cardiovascular disease Cardiovascular disease has emerged...
Polycystic ovary syndrome (PCOS) is a hormonal condition that primarily affects the ovaries. Lupus is a chronic autoimmune disease that involves inflammation in multiple organs and body tissues. People with PCOS may be at increased risk of developing lupus and other autoimmune diseases. This article explores the potential link between PCOS and lupus and provides...
Chocolate and cocoa products may help reduce inflammation, which may benefit people with autoimmune conditions such as lupus. However, there is no conclusive evidence that chocolate can reduce lupus symptoms. Lupus is a chronic autoimmune disease that can affect different parts of the body. With an autoimmune disease, the immune system cannot tell the difference between healthy tissues and pathogens. It...
Lupus can cause a variety of symptoms. Some individuals may experience changes in their fingernails and toenails. This may involve discoloration, infections, and changes in nail shape. Lupus refers to a long-term autoimmune condition. It occurs when the immune system mistakenly attacks healthy tissue, which can result in several possible symptoms. Potential symptoms of lupus can include changes to skin and nails....
by Wiley Credit: CC0 Public Domain Tyrosine kinases are enzymes that play central roles in signaling by cytokines involved in the pathogenesis of autoimmune diseases, including lupus. A recent phase 2 clinical trial published in Arthritis & Rheumatology has generated promising results for deucravacitinib, an oral inhibitor of tyrosine kinase 2 (TYK2), in patients with active lupus....
HOSPITAL FOR SPECIAL SURGERY After sun exposure, people with systemic lupus erythematosus (SLE) frequently develop skin rashes, which often are accompanied by a flare of their overall disease. This connection between ultraviolet (UV) light and disease flares in lupus is well known, but the way in which UV exposure actually triggers the disease has been...
by Bob Yirka , Medical Xpress Scanning electromicrograph of Staphylococcus aureus bacteria. Credit: NIAID A team of researchers at the Tohoku University Graduate School of Medicine, working with a colleague from Japan’s National Cancer Center, has found that the presence of Staphylococcus aureus on the skin of test mice with a lupus-like disease was found...
