Tony Ho Tran Deputy Editor, Innovation & Tech Updated Nov. 03, 2022 2:23 PM ET / Published Nov. 03, 2022 2:00 PM ET Yuichiro Chino via Getty Autoimmune disorders cause the body’s own defense system to attack normal, healthy cells. They can also leave people vulnerable to diseases—resulting in more severe and deadly infections. But...
by Denise Mann An experimental drug that has been shown to treat rashes in people with lupus may also help with lupus-related joint pain. Affecting as many as 1.5 million people in the United States, lupus is an autoimmune disease in which the body’s immune system misfires against its own joints, skin, brain, lungs, kidneys and blood...
by University of Michigan Transcriptional modulation by the LE (Model A: epitope + IFN-γ, versus IFN-γ alone). a Heatmaps showing unsupervised clustering of upregulated (left, yellow) and downregulated (right, purple) DEGs for 65-79*LE, 65-79*SE and 65-79*PE. DEGs were selected based on a > 3-fold change for 65-79*LE. All depicted DEGs had a Padj < 0.05. b Venn diagrams showing comparison of DEGs for 65-79*LE,...
MICHIGAN MEDICINE – UNIVERSITY OF MICHIGAN Researchers at Michigan Medicine have uncovered the molecular mechanism that drives the disease-causing effects of the most common genetic risk factor for lupus, a study suggests. Systemic lupus erythematosus is a common, incurable autoimmune disease that affects millions of individuals worldwide, with a particularly high prevalence among women. A...
A study suggests that researchers at Michigan Medicine have uncovered the molecular mechanism that drives the disease-causing effects of the most common genetic risk factor for lupus. Systemic lupus erythematosus is a common, incurable autoimmune disease affecting millions worldwide, with a particularly high prevalence among women. A genetic variant, called HLA-DRB1*03:01, is the greatest risk factor...
by Hokkaido University When mice that exhibit SLE-like symptoms are subjected to sleep deprivation stress, their neurons exhibit abnormal growth (left). When IL12 and 23 are blocked, the abnormal growth is reversed (right). Credit: Nobuya Abe et al, Annals of the Rheumatic Diseases (2022) Systemic lupus erythematosus (SLE) is an autoimmune disease that affects all the organ...
Published June 1, 2022 Permission granted by Bristol-Myers Squibb Dive Brief: Bristol Myers Squibb’s experimental autoimmune disease drug deucravacitinib helped treat moderate-to-severe lupus in a Phase 2 trial, the company reported Wednesday. Results, which were presented at a medical conference in Denmark, showed two doses of the pill led to significantly higher response rates than did...
This image shows a butterfly, the symbol for lupus (due to the typical “butterfly rash”), landing on the Y264H site of a flower grown from the protein structure of TLR7.- Jeroen Claus An international team of researchers has identified DNA mutations in a gene that senses viral RNA as a cause of the autoimmune disease lupus...
by Laurie Fickman, University of Houston Credit: CC0 Public Domain A globally renowned expert in autoimmune diseases and systemic lupus erythematosus (SLE) at the University of Houston has identified potential biomarkers for neuropsychiatric symptoms of lupus. Lupus is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue...
by National University of Singapore, Yong Loo Lin School of Medicine Credit: Pixabay/CC0 Public Domain Systemic lupus erythematosus (SLE) is an autoimmune disease in which the immune system attacks the body’s own tissues, causing widespread inflammation and damage in the affected organs. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. Asian...
