by Institute for Systems Biology Credit: Cell Systems (2025). DOI: 10.1016/j.cels.2025.101239 Researchers have uncovered a stealth survival strategy that melanoma cells use to evade targeted therapy, offering a promising new approach to improving treatment outcomes. The study, published in Cell Systems and conducted by researchers at the Institute for Systems Biology (ISB) and Massachusetts Institute of Technology (MIT), identifies a non-genetic,...
Tag: <span>MELANOMA</span>
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Targeted alpha therapy offers new hope for treating metastatic melanoma
Reviewed Chiba UniversityMar 12 2025 Metastatic melanoma, also known as stage IV melanoma, is a type of skin cancer that spreads to other parts of the body. It is one of the most aggressive forms of skin cancer, with current therapies—including immunotherapy and targeted drugs—showing limited effectiveness. Radiotherapy is an emerging treatment for melanoma, but conventional beta-emitting radionuclide...
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Researchers unveil a novel strategy to combat melanoma brain metastases
A new study reveals the key role of microglia, brain’s immune cells, in brain metastases progression and identifies a strategy to manipulate them to promote antitumor responses.Peer-Reviewed Publication Universidad Miguel Hernandez de Elche FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail image: The image shows microglial cells (in green) infiltrating tumor cells in a melanoma metastasis (in red). The cell nuclei are...
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Inhibiting a gene provides a new weapon to fight treatment-resistant melanoma
by The Wistar Institute Credit: Unsplash/CC0 Public Domain The lab of The Wistar Institute’s Jessie Villanueva, Ph.D., has identified a new strategy for attacking treatment-resistant melanoma: inhibiting the gene S6K2. The team has published their findings in a paper titled “Selective abrogation of S6K2 identifies lipid homeostasis as a survival vulnerability in MAPKi-resistant NRASMUT melanoma” in the journal Science Translational...
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Melanoma study identifies a mechanism for eliminating harmful cells from cancer treatment
by University of Barcelona Mechanism of apoptotic protection in senescent melanoma cells. Credit: Cell Death & Differentiation (2024). DOI: 10.1038/s41418-024-01417-z After treating a tumor with chemotherapy and radiotherapy, cells known as senescent cells can appear. These are cells that do not divide, are involved in the aging process, and are resistant to cell death, but are still metabolically...
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Unexpected Findings in Study of T Cells, Considered Front-line Fighters Against Advanced Melanoma
Posted Today Yale researchers made an unexpected discovery—turncoat T cells that help a tumor evade other cancer-fighting immune T cells—in a study of patients living with advanced melanomathat was published in Nature Immunology. Melanoma cells – artistic impression. Image credit: Gemini / Alius Noreika The study by Yale Cancer Center (YCC) researchers at Yale School of Medicine (YSM)...
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Tumor characteristics found to differ for melanomas in children, teens and young adults
by Elana Gotkine Tumor characteristics differ significantly among pediatric and adolescent and young adult (AYA) patients with melanoma, with decreasing incidence rates seen among young patients with cutaneous melanoma, according to a study published online Nov. 15 in the Journal of the American Academy of Dermatology. Bianca E. Ituarte, from the University of Nebraska Medical Center in Omaha,...
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Cutaneous malignant melanoma incidence increasing among the elderly
by Elana Gotkine From 1987 to 2016, there was a considerable increase in the incidence of cutaneous malignant melanoma (CMM) among the elderly in the United States, according to a study published online Oct. 28 in Cancer Screening and Prevention. ADVERTISING Ruofei Du, Ph.D., from Shaanxi University of Chinese Medicine in Xianyang, and colleagues examined CMM incidence trends...
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Tumor-specific antibodies able to detect melanoma in its earliest stages, new study shows
September 25, 2024 by European Academy of Dermatology and Venereology Innovative research has unveiled promising advancements in melanoma detection, which could significantly enhance diagnosis and prognosis by identifying the disease at its earliest, most treatable stages. This new method, presented today at the European Academy of Dermatology and Venereology (EADV) Congress 2024, uses tumor-specific profiling...
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Cell line models identify cause of melanoma with drug resistance
AMD1 inactivation sensitizes BRAF mutant melanoma to vemurafenib. Credit: Molecular Cancer (2024). DOI: 10.1186/s12943-024-02031-w Melanoma is a type of cancer that originates from melanocytes, the cells responsible for producing skin pigment, and is known as the most lethal form of skin cancer due to its high rates of metastasis and recurrence. With the global trend of aging...