NEW YORK (GenomeWeb) – A team led by researchers at the University of Maryland and the National Cancer Institute has developed a gene expression-based predictor of response to immune checkpoint blockade therapy in metastatic melanoma patients. In a study published yesterday in Nature Medicine, the scientists, led by senior author Eytan Ruppin and first author Noam Auslander,...
Tag: <span>MELANOMA</span>
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Scientists identify weak point in deadly eye melanoma
Plant compound shuts down tumor growth WASHINGTON UNIVERSITY SCHOOL OF MEDICINE A natural plant compound exploits a newly identified Achilles’ heel in a cancer of the eye, uveal melanoma. In human cancer cells growing in the lab, the compound shuts down the overactive signaling that drives uveal melanoma cell growth, according to researchers at Washington University School...
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Combination approach shows promise for beating advanced melanoma
In UCLA-led study, new treatment is more effective in people receiving immunotherapy for the first time UNIVERSITY OF CALIFORNIA – LOS ANGELES HEALTH SCIENCES A UCLA-led study has found that a treatment that uses a bacteria-like agent in combination with an immunotherapy drug could help some people with advanced melanoma, an aggressive form of skin...
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Research team develops predictor for immunotherapy response in melanoma
In a new study, researchers developed a gene expression predictor that can indicate whether melanoma in a specific patient is likely to respond to treatment with immune checkpoint inhibitors, a novel type of immunotherapy. The predictor was developed by Noam Auslander, Ph.D., with other researchers in the Center for Cancer Research (CCR) at the National Cancer Institute (NCI), part of the...
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Combination immunotherapy shrinks melanoma brain metastases
Combination immunotherapy shrank melanoma that has spread to the brain in more than half of the patients in a clinical trial reported in the New England Journal of Medicine led by an investigator at The University of Texas MD Anderson Cancer Center. Hussein Tawbi, M.D., Ph.D. Credit: MD Anderson Cancer Center Of 94 patients in the single-arm study combining...
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Retinoic acid may improve immune response against melanoma
Immunotherapies use the immune system to fight cancer. But cancers like melanoma have found ways to turn off the immune system, allowing them to resist treatments and often leading to recurrence. Now University of Colorado Cancer Center clinical trial results published today in the journal International Immunopharmacology describe a promising strategy to remove one of melanoma’s most...
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Drug combination targeting HSP90 and BRAF is safe and effective in advanced melanoma
XL888 Plus vemurafenib results in manageable toxicity and durable responses in advanced and metastatic melanoma patients TAMPA, Fla. – Patients with advanced or metastatic melanoma have been able to live longer cancer-free lives because of several new therapies approved over the last decade, such as BRAF and MEK inhibitors. However, despite the success of these...
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Cancer immunotherapy uses melanin against melanoma
Researchers have developed a melanin-enhanced cancer immunotherapy technique that can also serve as a vaccine, based on early experiments done in a mouse model. The technique is applied via a transdermal patch (shown here) and is made more …more Researchers have developed a melanin-enhanced cancer immunotherapy technique that can also serve as a vaccine, based...
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Lung cancer driver ALK-fusion found in melanoma
Melanomas caused by sun exposure have been matched with targeted treatments and immunotherapies, in many cases dramatically extending patients’ lives. However, there are other kinds of melanoma not related to sun exposure and because they are caused by different genetic changes, they are not susceptible to the same targeted treatments. This often leaves patients...
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Researchers look to protect ‘self-reactive’ immune cells so they can fight melanoma
CHAPEL HILL — Researchers at the University of North Carolina Lineberger Comprehensive Cancer Center are using what they know about a rare, inherited autoimmune disease to turn the body’s defenses against melanoma. In JCI Insight, researchers report on a potential new way to fight melanoma by blocking one of the immune system’s checks and balances. Combining...