The findings, demonstrated in mouse models and isolated human brain tissue, could expand treatment options for neurological and psychiatric diseasesPeer-Reviewed Publication The Mount Sinai Hospital / Mount Sinai School of Medicine FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail image: Blood–brain-barrier-crossing lipid nanoparticles (BLNPs) effectively and safely deliver mRNA to the brain via systemic administration. view more Credit: Created with BioRender.com in the lab...
Tag: <span>nanoparticle</span>
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Egyptian scientists use gold nanoparticles to reverse obesity-related damage in rat study
by Justin Jackson , Phys.org Credit: Pixabay/CC0 Public Domain High-dose gold nanoparticle treatment outperformed orlistat in reversing obesity-related damage in rats, according to research conducted by Alexandria University, Erbil Polytechnic University, and Pharos University. Gold nanoparticles (AuNPs) demonstrated significant anti-obesity effects, reducing body fat, improving metabolic health, and restoring organ function in rats with diet-induced...
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Solving the drug solubility problem with silica nanoparticles
by Justin Jackson , Phys.org The adsorption of API and water molecules on silica surfaces with different silanol densities. Credit: Proceedings of the National Academy of Sciences (2025). DOI: 10.1073/pnas.2423426122 Harvard University and the Chinese University of Hong Kong researchers have developed a technique that increases the solubility of drug molecules by up to three orders of...
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Nanoparticle-Delivered RNA Reduces Neuroinflammation in Lab Tests
MIT researchers find that in mice and human cell cultures, lipid nanoparticles can deliver a potential therapy for inflammation in the brain, a prominent symptom in Alzheimer’s.Some Covid-19 vaccines safely and effectively used lipid nanoparticles (LNPs) to deliver messenger RNA to cells. A new MIT study shows that different nanoparticles could be used for a...
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Scientists create nanoparticle that helps fight solid tumors
by Wake Forest University Baptist Medical Center Design and characterization of NP700-ARL. (A) Scheme illustration of the self-assembly of NP700-ARL. In this delivery system, (1) the photosensitizer-containing lipid polymer DSPE-PEG-IR700 is a “ROS-producing” component, which damages tumor cells and induces ATP release under light irradiation; at the same time, it produces ROS as stimuli to...
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A nanoparticle and inhibitor trigger the immune system, outsmarting brain cancer
MICHIGAN MEDICINE – UNIVERSITY OF MICHIGAN IMAGE: GLIOMA CELLS CREDIT: UNIVERSITY OF MICHIGAN ROGEL CANCER CENTER ANN ARBOR, Michigan — Scientists at the University of Michigan Rogel Cancer Center were optimistic when they identified a small molecule that blocked a key pathway in brain tumors. But there was a problem: How to get the inhibitor...
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Nanoparticle reduces skin and lung scarring for scleroderma, mouse study finds
The findings provide promise of targeted treatment for patients with the disease. Investigators have discovered that a biodegradable nanoparticle used in medical sutures could combat a rare, sometimes-fatal autoimmune disease. Researchers found that a unique macrophage, an immune cell that removes bacteria or dead cells, plays a key role in the chronic inflammation and scarring...
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Clearing cholesterol crystals with a new nanoparticle
An innovative nanoparticle could one day help address an untreatable risk factor for heart attacks and strokes: cholesterol crystals that trigger inflammation and evade medications. “Although lipid-lowering drugs substantially prevent cardiovascular events in atherosclerosis, some patients still suffer from high residual risk because the existing cholesterol crystals in the atherosclerotic plaques activate immune cells and...
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Nanoparticle therapeutic enhances cancer immunotherapy
WAKE FOREST BAPTIST MEDICAL CENTER IMAGE: DAWEN ZHAO, M.D., PH.D., ASSOCIATE PROFESSOR OF BIOMEDICAL ENGINEERING AT WAKE FOREST SCHOOL OF MEDICINE, AND TEAM HAVE DISCOVERED THAT A NANOPARTICLE THERAPEUTIC ENHANCES CANCER IMMUNOTHERAPY AND IS A POSSIBLE NEW APPROACH IN TREATING MALIGNANT PLEURAL EFFUSION (MPE). CREDIT: WAKE FOREST SCHOOL OF MEDICINE WINSTON-SALEM, N.C. – Dec. 16,...
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Nanoparticle drug delivery technique shows promise for treating pancreatic cancer
VETERANS AFFAIRS RESEARCH COMMUNICATIONS IMAGE: STUDY RESEARCHERS DRS. SNIGDHA BANERJEE, SUMAN KAMBHAMPATI, SUSHANTA BANERJEE, AND A COLLEAGUE EXAMINE A PANCREATIC CANCER IMAGE. CREDIT: JEFF GATES Researchers with the Kansas City Veterans Affairs Medical Center and North Dakota State University have designed a new way to deliver pancreatic cancer drugs that could make fighting the disease much easier. Encapsulating...
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