by University of North Carolina at Chapel Hill Chirality inversion mechanisms. Scheme and TEM images (a) of Fmoc-FFFF-PEG2 prepared at RT, or heated to 37 and 40 °C to track the chirality inversion (50 nm scale bars). Schematic (b) of seeded growth via right-handed nucleation points. CD spectra (c) of nucleated assemblies grown with varying monomer:seed ratios. TEM...
by The Mount Sinai Hospital blood donationCredit: Pixabay/CC0 Public DomainA novel treatment for polycythemia vera, a potentially fatal blood cancer, demonstrated the ability to control overproduction of red blood cells, the hallmark of this malignancy and many of its debilitating symptoms in a multi-center clinical trial led by the Icahn School of Medicine at Mount...
by QIMR Berghofer Graphical overview of epigenetic reprograming in hamster bronchiolar epithelium and human CD14+ monocytes. Credit: Nature Communications (2023). DOI: 10.1038/s41467-023-39341-4 A new drug developed by QIMR Berghofer could transform the treatment of COVID-19 by potentially protecting against infection by any SARS-CoV-2 variant and reversing the persistent inflammation that is a major driver of debilitating long COVID....
by University of Auckland P2X3-receptor antagonism improves cardiac function in chronic heart failure (CHF) rats. a Representative images of echocardiography in rats submitted to myocardial infarction (MI), before and after 7 weeks of treatment with vehicle or AF-130. Red arrows indicate diastolic ventricular diameter and yellow arrows indicate diastolic ventricular wall thickness. P2X3-receptor antagonism prevented...
by University of Texas Health Science Center at San Antonio Mitochondria in a single heart cell. Mitochondria highlighted in red were exposed to ultraviolet light. Credit: National Heart, Lung and Blood Institute, National Institutes of Health Researchers from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) have developed a small-molecule...
Mitchel L. Zoler, PhD March 14, 2023 NEW ORLEANS – An investigational, first-in-class agent that delivers a completely new type of intervention to patients with pulmonary arterial hypertension (PAH) scored a clear win in the STELLAR trial, the first to complete among three phase 3 trials that are testing this agent. Sotatercept, administered subcutaneously every 3 weeks for 24...
by Public Library of Science Drosophila that represents one of the models of neurodegeneration used in the lab to screen for things (both chemically and genetically) that regulate mitophagy. Credit: Angus McQuibban (CC-BY 4.0, https://creativecommons.org/licenses/by/4.0/) The words that researchers use to describe their results can be harnessed to discover potential new treatments for Parkinson’s disease, according to a...
UNIVERSITY OF PENNSYLVANIA SCHOOL OF MEDICINE NEW ORLEANS – A first-of-its-kind drug known as modakafusp alfa has shown early potential in combating multiple myeloma, a form of bone marrow cancer, in a study presented by researchers from the University of Pennsylvania’s Abramson Cancer Center at the 2022 American Society of Hematology (ASH) Annual Meeting (Abstract 565). Patients in...
by University of Cincinnati Micrograph showing cortical pseudolaminar necrosis, a finding seen in strokes on medical imaging and at autopsy. H&E-LFB stain. Credit: Nephron/Wikipedia A new groundbreaking study from the University of Cincinnati shows promise that a new drug may help repair damage caused by strokes. Researchers from UC and Case Western Reserve University published...
by The Ohio State University Credit: Unsplash/CC0 Public Domain Researchers at The Ohio State University Wexner Medical Center and College of Medicine have developed a novel drug molecule that targets T-cells causing inflammation in heart failure patients, stopping further progression of the disease. During heart failure, T-cells, which are part of the immune system, go from...
