by The Korea Advanced Institute of Science and Technology (KAIST) Schematic diagram of the mechanism of retinal regeneration through inhibition of PROX1 migration. PROX1 protein secreted from damaged retinal nerve cells migrates to Müller glia and inhibits dedifferentiation into neural progenitor cells and neural regeneration. When PROX1 is captured outside the cells with a neutralizing antibody...
Tag: <span>retinal</span>
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An old drug finds new purpose against retinal neovascularization
Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have found that the anti-malaria drug amodiaquine inhibits the apelin receptor protein, which helps drive the vascularization behind diabetic retinopathy, wet age-related macular degeneration (AMD) and other conditions. Because the drug has been approved to treat malaria for decades, it could move relatively quickly through the...