by University of California, Irvine Lipid-filled cartilage of mammals. Unlike in conventional cartilage, the form and function of lipid-filled cartilage derives from giant lipid vacuoles (center). Vacuolated cartilage in mammals represents convergent evolution with the notochord, which has cells containing giant aqueous vacuoles. Developing cartilage grows vacuoles by a tightly controlled biochemical pathway (bottom). Mature lipocartilage...
Tag: <span>Skeletal Health</span>
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Effects of Geroprotective Drugs on Skeletal Health are Largely Unknown
The various geroprotective drugs capable of upregulating cellular maintenance processes in order to modestly slowing aging in short-lived laboratory species are a mixed bunch, ranging from the only technically geroprotective, including well characterized, and well used drugs such as aspirin, to drugs with very mixed data for small effects, such as metformin, through to the better end of the...