by Johannes Angerer, Medical University of Vienna Proteomic analysis of small-cell lung cancer (SCLC) cell lines highlights molecular heterogeneity: (A) The mRNA expression of key genes ASCL1, NEUROD1, POU2F3 and YAP1 to determine the molecular subtypes (top). Data is shown as mean ± SD of the 2−ΔCt × 1000 value, normalized to glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Each dot represents...
by Ohio State University Medical Center Credit: CC0 Public Domain A new study of advanced small-cell lung cancer (SCLC) led by researchers at The Ohio State University Comprehensive Cancer Center—Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC—James) has identified molecular patterns linked to patients developing resistance to certain therapies. This study, published in the journal JTO...
by National Institutes of Health Killer T cells surround a cancer cell. Credit: NIH Researchers from the National Institutes of Health have identified and tested a drug combination that exploits a weakness in small cell lung cancer (SCLC), an aggressive, dangerous cancer. The scientists targeted a vulnerability in how the cancer cells reproduce, increasing already high...
UNIVERSITY OF COLOGNE IMAGE: Small cell lung cancer cells in culture (blue), non-endocrine cells are stained red. CREDIT: CHRISTINA BEBBER Using samples of small cell lung tumours, a research team led by biologist Dr Silvia von Karstedt has discovered two new ways to induce tumour cell death. One of two subsets of tumour cells can be targeted...
by University of Texas M. D. Anderson Cancer Center Researchers from The University of Texas MD Anderson Cancer Center have developed the first comprehensive framework to classify small-cell lung cancer (SCLC) into four unique subtypes, based on gene expression, and have identified potential therapeutic targets for each type in a study published today in Cancer Cell. SCLC is...
(Reuters) – U.S. regulators have approved AstraZeneca Plc’s Imfinzi treatment for use against an aggressive type of lung cancer in previously untreated patients, the group said on Monday, as it moves to expand its specialization in tackling the disease. The treatment, when combined with chemotherapy, was approved by the U.S. Food and Drug Administration for...
