Mutations in the gene encoding the enzyme protein tyrosine phosphatase N2 (PTPN2) have been associated with the development of autoimmune disease including Type 1 diabetes, Crohn’s Disease and rheumatoid arthritis. In important fundamental research, Monash University researchers have identified a crucial part of the enzyme’s role in early T-cell development, and have shown that decreased levels...
Tag: <span>T cell development</span>
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Statistical analysis for optimal immunization: New insights into T cell development
When T cells encounter an antigen, they proliferate and produce various types of daughter cells. A team at the Technical University of Munich (TUM) has now refuted the prevailing hypothesis that this immune response is largely predetermined by the individual structure of the T cell receptor. Instead, the influence of the T cell receptor can...