By Susha Cheriyedath, M.Sc. Jul 13 2023 Reviewed by Benedette Cuffari, M.Sc. A recent study published in Scientific Reports investigates the persistence of symptoms and the immune response in patients recovering from the coronavirus disease 2019 (COVID-19). Study: Cellular immunity reflects the persistent symptoms among COVID-19-recovered patients in Japan. Image Credit: Kateryna Kon / Shutterstock.com Background Infection with the...
by University of Pittsburgh Universal adaptor SNAP-CAR and SNAP-synNotch receptor function. a A benzylguanine motif (BG) is chemically conjugated to an antibody using a benzylguanine NHS ester. The BG-antibody conjugate then covalently binds to the extracellular SNAPtag enzyme through a self-labeling reaction. b SNAPtag receptors enable the targeting of multiple different antigens using the same receptor...
By Paul McClure April 05, 2023 Researchers have created a new type of genetically engineered chimeric antigen receptor (CAR) T-cell that shows great promise in treating solid cancer tumors Maja Divjak/Peter MacCallum Cancer Center Cancer cells are notorious for evading detection by the body’s immune system, making them difficult to treat. But a promising new...
by St. Jude Children’s Research Hospital Scanning electron micrograph of human T lymphocyte or T cell. Credit: NIAID/NIH Chimeric antigen receptor (CAR) T-cell therapy is immunotherapy that is making a clinical difference for patients with some blood cancers, solid tumors and chronic viral infections. Scientists at St. Jude Children’s Research Hospital have now identified how an...
Cambridge researchers have discovered how T cells – an important component of our immune system – are able to keep on killing as they hunt down and kill cancer cells, repeatedly reloading their toxic weapons. Cytotoxic T cells are specialist white blood cells that are trained by our immune system to recognise and eliminate threats...
by University of Cambridge Credit: CC0 Public Domain Cambridge researchers have discovered how T cells—an important component of our immune system—are able keep on killing as they hunt down and kill cancer cells, repeatedly reloading their toxic weapons. Cytotoxic T cells are specialist white blood cells that are trained by our immune system to recognize and...
Messenger-RNA (mRNA) vaccines against the coronavirus that causes COVID-19 provoke a swift and strong response by the immune system’s T cells—the heavy armor of the immune system—according to a study from researchers in the Perelman School of Medicine at the University of Pennsylvania. Although recent studies of vaccines tend to focus on the antibody response,...
by Duke-NUS Medical School Graphical Abstract. Cell Reports (2021). DOI: 10.1016/j.celrep.2021.108728 Antibodies and T cells are components of the human immune system that directly act against viral infections and eliminate infected cells. A new study by scientists from Duke-NUS Medical School, provides evidence that an early presence of SARS-CoV-2-specific T cells in COVID-19 is likely to prevent severe...
Posted by Kathleen Hoffman Something unusual happened when Professor Andrew Sewell and the T-Cell Modulation Group at the University of Cardiff put the blood of a healthy donor in a petri dish with some cancer cells. What grew in the blood was a T-cell that no one had seen before. This T-cell attacked the cancer cells...
By Dr. Sanchari Sinha Dutta, Ph.D.Sep 8 2020 A recent study demonstrates that functional CD4+ and CD8+ T cells specifically targeting the entire proteome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain active in individuals who have recovered from severe or mild coronavirus disease 2019 (COVID-19). Moreover, the magnitude of T cell response is correlated with the...
