by University of Technology, Sydney Credit: Pixabay/CC0 Public Domain Research led by the Centenary Institute, the University of Technology Sydney and Ghent University Hospital, Belgium has identified a new therapeutic approach for chronic obstructive pulmonary disease (COPD)—the targeting and inhibition of a protein called RIPK1. The third leading cause of death worldwide and with no...
by University of Texas Health Science Center at San Antonio PET scan of a human brain with Alzheimer’s disease. Credit: public domain Scientists from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) today reported that an inflammatory trigger like one present during viral infections is elevated in Alzheimer’s disease...
by McMaster University Credit: Unsplash/CC0 Public Domain Long-term consumption of Allura Red food dye can be a potential trigger of inflammatory bowel diseases (IBDs), Crohn’s disease and ulcerative colitis, says McMaster University’s Waliul Khan. Researchers using experimental animal models of IBD found that continual exposure to Allura Red AC harms gut health and promotes inflammation. The...
by Salk Institute Salk researchers discovered the compound FexD can treat intestinal inflammation in mice. Mice with symptoms similar to inflammatory bowel disease had changes to the cells lining their intestines (left) that were reversed with treatment (right). Credit: Salk Institute A drug developed by Salk Institute researchers acts like a master reset switch in...
by Alyssa Tomlinson, University of Maryland Generation and validation of MUC5B/AC-KO cultures. (A) Overview of the MUC5B/MUC5AC gene-targeting approach via lentivirus-mediated delivery of sgRNA and CRISPR-Cas9. Transduced and sorted cells were differentiated at air-liquid interface (ALI). Once fully differentiated, the mucus gel was collected by apically washing cultures. HEK293T, human embryonic kidney–293T; FACS, fluorescence-activated cell...
by Ingrid Fadelli, Medical Xpress GFAP immunostaining of an iPSC-derived astrocyte displaying a stellate ramified morphology in co-culture with iPSC-derived neurons (not visualized). Credit: Leng et al. Astrocytes or astroglia, the largest glial cell population in the central nervous system (CNS), perform numerous vital functions. Among other things, these glial cells (i.e., cells supporting functions...
by University of Wisconsin-Madison This schematic illustration shows probiotic bacteria (teal) coated in a layer of biomaterial as they travel through a human intestine. Attached to the bacteria are reactive oxygen species nano-scavengers. Credit: Quanyin Hu Like elite firefighters headed into the wilderness to combat an uncontrolled blaze, probiotic bacteria do a better job quelling...
by Bob Yirka , Medical Xpress Scanning electromicrograph of Staphylococcus aureus bacteria. Credit: NIAID A team of researchers at the Tohoku University Graduate School of Medicine, working with a colleague from Japan’s National Cancer Center, has found that the presence of Staphylococcus aureus on the skin of test mice with a lupus-like disease was found...
by University of Miami Graphical abstract. Credit: American Journal of Physiology-Gastrointestinal and Liver Physiology (2022). DOI: 10.1152/ajpgi.00159.2022 Many alcoholic pancreatitis patients continued drinking during COVID-19. University of Miami Miller School of Medicine researchers are studying the effects of continued alcohol intake and seeking better treatment for alcohol-associated pancreatic disease. The researchers are looking for solutions to the...
by NYU Langone Health Credit: Pixabay/CC0 Public Domain Blocking the action of calcium signals in immune cells suppresses the most common form of asthma, but without compromising the body’s defenses against flu viruses, a new study finds. Led by researchers at NYU Grossman School of Medicine, experiments showed that removing the gene for a calcium channel—specifically...
