by Annalena Huber, Max Planck Society In the study, biological data was gathered from participants. Based on different patterns in the data, the researchers grouped participants into four clusters. Credit: Janine Knauer-Arloth Roughly one-third of patients with depressive symptoms have elevated levels of inflammation. Inflammation is, however, often only measured using very broad and unspecific markers....
Category: <span>Inflammation</span>
New technique allows technicolor imaging of degenerative joint disease
by Ashley WennersHerron, Pennsylvania State University Researchers developed novel contrast agents that target two proteins implicated in osteoarthritis, a degenerative joint disease commonly characterized as wear-and-tear arthritis, and imaged the proteins using a photon-counting CT scanner. Here, the green and red are the targeted nanoparticles, while the yellow is adipose tissue. The white is bone and...
Psoriasis patients can get clearer skin with at-home treatment instead of at doctors’ offices, study suggests
by Alex Gardner, Perelman School of Medicine at the University of Pennsylvania Credit: Estzer Miller on Pixabay For decades, people with psoriasis have been treated in clinics with narrowband ultraviolet B phototherapy, or light therapy, to reduce sores, scales, and inflammation. Now, new research from the Perelman School of Medicine at the University of Pennsylvania shows...
Mouse model reveals liver involvement in muscular dystrophy
by Liz Ahlberg Touchstone, University of Illinois at Urbana-Champaign In muscular dystrophy type 1, mutated DNA begets toxic RNA that alter liver function, including susceptibility to fatty liver disease and hypersensitivity to drugs. Understanding these effects is crucial for developing treatments, as many have proven toxic in patients. Credit: Haneni Bae, University of Illinois at Urbana-Champaign...
Researchers discover how chronic inflammation worsens heart failure
by Sarah C. P. Williams, Gladstone Institutes Stress-activated Cx3cr1+ macrophages contribute to heart failure pathogenesis. Credit: Nature (2024). DOI: 10.1038/s41586-024-08085-6 If you cut your arm or undergo surgery, scarring can be a good thing; the scar tissue produced by cells called fibroblasts helps you heal. In most organs of the body, however, the accumulation of scarring (called fibrosis) is...
Researchers uncover key to preventing fibrosis in biomaterial implants
by University of Virginia Hydrogel fabrication and subcutaneous implantation. Credit: Science Advances (2024). DOI: 10.1126/sciadv.adf2675 A study from the University of Virginia’s Department of Biomedical Engineering has identified a critical mechanism driving fibrosis, or scarring, in response to medical implants made with biomaterial hydrogels. Their discovery, published in the June 14 issue of Science Advances, offers new hope for improving the...
Antibody that reduces inflammation may serve as cardio-immunotherapy for heart failure patients
by Washington University School of Medicine Researchers at WashU Medicine have reduced scar formation and improved heart function in mouse models of heart failure using a monoclonal antibody treatment. Untreated mice develop major scarring after cardiac injury (purple tissue, left) while treated animals show much less scarring (right). The findings point to the possibility of developing...
How Do Tapinarof and Roflumilast Creams Fit Into Psoriasis Treatment?
HUNTINGTON BEACH, Calif. — The US Food and Drug Administration (FDA) approvals of tapinarof 1% cream and roflumilast 0.3% cream as treatment options for patients with plaque psoriasis came more than 1 year after the American Academy of Dermatology/National Psoriasis Foundation Guidelines of care for the management and treatment of psoriasis with topical therapy and alternative medicine...
Systemic inflammation may play a role in how air pollution contributes to cognitive impairment
by Raphaël Cayrol, University of Luxembourg Hypothesized pathogenic pathways taken by fine particulate matter (PM2.5) to cause cognitive impairment. PM2.5, particulate matter with a diameter of 2.5 µm and smaller. Two main hypotheses exist regarding the underlying mechanisms of how inflammatory processes are involved in the pathogenic effects of PM2.5 on the development of neurodegenerative diseases: The...
Comorbidities Associated With Psoriasis: 5 Things to Know
Psoriasis is an immune-mediated chronic inflammatory skin disease that affects approximately 2%-4% of adults in Western countries. Over the past decade, discovery of the pathogenic pathways in psoriasis has led to a greater understanding of the role psoriasis plays in systemic inflammation and associated comorbidities. Several recent studies have shown that patients with psoriasis have higher rates of comorbid...