by Osaka University Fig. 1. Amount of hydrogen generated per 1 g of the mouse gastrointestinal tract in the control group compared with in the mice given the silicon (Si)-based agent. Credit: Scientific Reports (2022). DOI: 10.1038/s41598-022-13655-7 Many people worldwide suffer from a chronic type of inflammatory bowel disease (IBD) called ulcerative colitis (UC), which is characterized by...
Smoking, but not alcohol consumption, is causally associated with psoriasis, according to a study published online June 28 in the British Journal of Dermatology. Jiahe Wei, from Hangzhou Medical College in China, and colleagues examined the causal associations of alcohol consumption and smoking with psoriasis using genome-wide association study (GWAS) summary-level data for alcohol consumption, smoking initiation, cigarettes per day,...
by Hudson Institute of Medical Research TLR-induced inflammasome priming triggers IL-1β and NLRP3 ubiquitylation. a BMDMs were primed with Lipopolysaccharide (LPS, 50 ng/ml) for up to 8 h (hr) and ubiquitylated (Ub.) proteins were isolated from cell lysates by Tandem Ubiquitin Binding Entity (TUBE) purification. Immunoblots were performed on cell lysates (input) and purified ubiquitylated proteins (TUBEs) for the...
by Hokkaido University When mice that exhibit SLE-like symptoms are subjected to sleep deprivation stress, their neurons exhibit abnormal growth (left). When IL12 and 23 are blocked, the abnormal growth is reversed (right). Credit: Nobuya Abe et al, Annals of the Rheumatic Diseases (2022) Systemic lupus erythematosus (SLE) is an autoimmune disease that affects all the organ...
by Edith Cowan University Credit: Pixabay/CC0 Public Domain New research led by Edith Cowan University has made an important discovery that could lead to more effective treatments for the world’s 262 million asthma sufferers. A study led by Dr. Stacey Reinke (ECU) and Dr. Craig Wheelock (Karolinska Institute, Sweden) found severe asthmatics have a distinct biochemical...
by University of Queensland Credit: Pixabay/CC0 Public Domain Researchers have isolated five strains of gut bacteria that could pave the way for new inflammatory bowel disease treatments and potentially help prevent some forms of bowel cancer. The study by University of Queensland and Mater researchers identified gut bacterial strains that suppress inappropriate gut inflammation and...
by Delthia Ricks, Medical Xpress scRNAseq replicates. CD45.1+ P14 cells were adoptively transferred into adult CD45.2+ GP or GFAP:GP mice 24h before i.c. infection with rLCMV-GP33. At least six weeks later, mice were treated with antiCD8a depleting antibody or isotype control. One week after depletion, mice were treated with TAM i.p. for four consecutive days...
by Universitaet Tübingen Credit: Pixabay/CC0 Public Domain Alzheimer’s, Parkinson’s and other neurodegenerative diseases are associated with inflammatory processes in the brain. German researchers have succeeded in identifying a group of proteins in cerebrospinal fluid that could provide information about such inflammatory processes. As so-called biomarkers, the proteins could help researchers to better understand disease processes in...
by Adrianna MacPherson, University of Alberta Credit: CC0 Public Domain New research shows a group of enzymes may have a critical role in the process of how immune cells are activated and then migrate to certain sites in the body—findings that could improve our understanding of inflammation and potentially lead to new treatments. In a...
CACTUS COMMUNICATIONS IMAGE: ROLE OF MACROPHAGES IN THE TRANSITION TO CHRONIC KIDNEY DISEASE, AND THE THERAPEUTIC STRATEGIES TO BLOCK THIS TRANSITION, ARE EXPLORED. CREDIT: CHINESE MEDICAL JOURNAL Acute kidney injury (AKI) is a condition in which kidneys are unable to filter waste from the blood effectively, leading to various health complications. Numerous studies have demonstrated...
