UNIVERSITY OF MÜNSTER IMAGE: PLATELETS (RED) INTERACTING WITH REGULATORY T CELLS (YELLOW) IN THE BACTERIALLY INFLAMED LUNG TISSUE OF A MOUSE. RESEARCHERS EXAMINED THE LIVING TISSUE USING CONFOCAL FLUORESCENCE MICROSCOPY. CREDIT: ROSSAINT ET AL./JEXPMED 2021 Treating patients with acute respiratory failure is a constant challenge in intensive care medicine. In most cases, the underlying cause...
GERMAN CANCER RESEARCH CENTER (DEUTSCHES KREBSFORSCHUNGSZENTRUM, DKFZ) A particular type of dendritic cell is responsible for the tissue damage that occurs in non-alcoholic steatohepatits (NASH) in mice and humans. The dendritic cells cause aggressive, proinflammatory behavior in T cells, as now discovered by researchers from the German Cancer Research Center (DKFZ) in collaboration with colleagues...
INSTITUT PASTEUR Inserm teams led by Laurent Reber (Infinity, Toulouse) and Pierre Bruhns (Humoral Immunity, Institut Pasteur, Paris) and French company NEOVACS have developed a vaccine that could induce long-term protection against allergic asthma, reducing the severity of its symptoms and thus significantly improving patient quality of life. Their research in animals has been published in the...
Dental and orthopedic implants are widely used around the world. Common causes for implant failure are the immune response against oral bacteria and titanium particles shed by the implant. These and other phenomena can generate an inflammatory response, activating the osteoclasts (bone resorbing cells), and ultimately leading to osteolysis (destruction of bone tissue) around the...
NIH/NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES IMAGE: GLUCOCORTICOIDS AND ANDROGENS PROMOTE A HEALTHY STOMACH PIT BY INHIBITING INFLAMMATION, LEFT, WHILE THEIR ABSENCE PROMOTES INFLAMMATION AND SPEM SEEN IN A DISEASED PIT, RIGHT. SPEM GLANDS ARE ALSO MUCH LARGER THAN HEALTHY STOMACH GLANDS. CREDIT: JONATHAN BUSADA, PH.D./NIEHS Scientists at the National Institutes of Health determined that...
Researchers at University of California San Diego School of Medicine have begun a pilot clinical trial to test the efficacy of using ultrasound to stimulate the spleen and reduce COVID-19-related inflammation, decreasing the length of hospital stays. “It’s a pilot study to evaluate whether ultrasound stimulation focused on the spleen can reduce inflammatory biomarkers in hospital...
by Nara Institute of Science and Technology ACA ameliorates mitochondrial damage, leading to the suppression of NLRP3-inflammasome activity and subsequent IL-1b release. Credit: Nara Institute of Science and Technology Many natural compounds have various anti-inflammatory and other beneficial properties that humans have been utilizing for medicinal purposes for hundreds of years. However, the specific molecular...
by Michael Addelman, University of Manchester Credit: Estzer Miller on Pixabay A novel drug almost entirely cleared moderate to severe psoriasis in over 60% of the patients who took part in two phase three clinical trials of a new drug. The University of Manchester and Salford Royal NHS Foundation Trust led studies on Bimekizumab , both...
by Federico Graciano, Duke-NUS Medical School Microscope imagining showing colocalisation of MOCCI (red) with a mitochondrial protein (green). Credit: Duke-NUS Medical School A multidisciplinary team of researchers from Duke-NUS Medical School and the Agency for Science, Technology and Research (A*STAR) in Singapore has discovered a new mitochondrial peptide called MOCCI that plays an important role in regulating inflammation of blood...
by University of Pittsburgh Credit: CC0 Public Domain Wheezing, coughing that doesn’t stop, a pale and sweaty face: clinically, severe asthma attacks look very similar from patient to patient. But biologically, not all severe asthma is the same—and a team of scientists has, for the first time, identified the key difference in people, a finding that has...
