CHICAGO (AP) — Almost one-third of new drugs approved by U.S. regulators over a decade ended up years later with warnings about unexpected, sometimes life-threatening side effects or complications, a new analysis found. The results covered all 222 prescription drugs approved by the U.S. Food and Drug Administration from 2001 through 2010. The researchers looked...
Category: <span>Pharmaceutical Updates</span>
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New drug-delivery method doubles duration of ibuprofen
Ibuprofen could soon be supercharged thanks to researchers at Northwestern University While graphene can claim the title of science’s sexiest wonder material, other substances called metal-organic-frameworks or MOFs, have been quietly changing the world while their single-atom-thick cousin hogs the spotlight. Now, researchers at Northwestern University (NU) have used MOFs to extend the speed and duration of...
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Keratin hydrogels show significant potential to regenerate lost muscle tissue and function
The use of human hair-derived keratin biomaterials to regenerate skeletal muscle has shown promise in new research that documents significant increases in both new muscle tissue formation and muscle function among mouse models of volumetric muscle loss. Two new studies that compare muscle regeneration following treatment with keratin hydrogels, no repair, or an alternative tissue...
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Novel gene therapy experiment offers hope for people with certain hearing loss and dizziness disorder
This image shows stereocilia bundles on inner hair cells from whirler mice after whirlin gene therapy. These hair-like protrusions allow sensory hair cells to detect sound and motion. The whirler mutant mouse has very short stereocilia bundles. After whirlin gene therapy, the stereocilia bundles are increased to normal length (red) and whirlin expression is restored...
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Preliminary study suggests possible new treatment for MS
A small, preliminary study may show promise of a new type of treatment for progressive multiple sclerosis (MS). Results from the first six people enrolled in the phase 1 study, a study designed to enroll 10 people, are being presented at the American Academy of Neurology’s 69th Annual Meeting in Boston, April 22 to 28,...
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Removing Old Cells Could Prove Effective In Stopping Osteoarthritis
The signs of aging can be a literal pain, especially for those with sedentary lifestyles who are more prone to experiencing joint and muscle pains. While professionals recommend having an active lifestyle to lower the risk of osteoarthritis development, researchers look inside our own bodies to determine how to fight the natural course of aging. A previous study found...
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A steroid jab in the bottom could ease hip pain caused by osteoarthritis for up to 12 weeks
The steroid injection was trialled by researchers in the Netherlands Relief period matched that of steroid injections directly into the affected joint The buttock jab is much less painful and can be administered by GPs An estimated nine million people in Britain have some degree of osteoarthritis A single steroid injection to the buttocks could...
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A New “CRISPR Pill” Makes Bacteria Destroy Its Own DNA
IN BRIEF An innovative study in the University of Wisconsin-Madison could soon put an end to drug-resistant bacteria by using an edible version of CRISPR. This probiotic could target specific bacteria, making it more effective than antibiotics. TARGETED AND EDIBLE As antibiotic resistance continues to grow, scientists are desperately trying to figure out how to best...
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Scientists ID two molecules that inhibit proteins involved in chronic inflammatory disease
Representative conformations of T23 in TNF and RANKL. Scientists have identified two small molecules that could be pursued as potential treatments for chronic inflammatory diseases. According to a paper published in PLOS Computational Biology, the researchers singled out the molecules using a new drug screening approach they developed. Both molecules, known as T23 and T8, inhibit...
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Science or Snake Oil: can turmeric really shrink tumours, reduce pain and kill bacteria?
Turmeric is a yellow coloured spice widely used in Indian and South East Asian cuisine. It’s prepared from the root of a plant called Curcuma longaand is also used as a natural pigment in the food industry. In the literature, curcumin is reported to be an antioxidant that protects the body against damage from reactive molecules. These are...