A study led by scientists at Monash University has shown that a new therapy developed through stem cell technology holds promise as a treatment for chronic asthma. The Monash Biomedicine Discovery Institute (BDI) scientists provided the experimental expertise to test Cynata Therapeutics’ induced pluripotent stem cell-derived mesenchymal stem cells (MSCs) in a model of experimental asthma. Induced pluripotent...
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First ‘haploid’ human stem cells could change the face of medical research
Stem cell research holds huge potential for medicine and human health. In particular, human embryonic stem cells (ESCs), with their ability to turn into any cell in the human body, are essential to the future prevention and treatment of disease. Most of the cells in our body are diploid, which means they carry two sets...
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Stem-cell researchers solve mystery of relapse in acute myeloid leukemia
Leukemia researchers led by Dr. John Dick have traced the origins of relapse in acute myeloid leukemia (AML) to rare therapy-resistant leukemia stem cells that are already present at diagnosis and before chemotherapy begins. They have also identified two distinct stem-cell like populations from which relapse can arise in different patients in this aggressive cancer...
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Human enzyme may be key to unraveling Alzheimer’s disease
Protein aggregates are the hallmark of a number of neurodegenerative diseases. New research, published in the journal PLOS Biology, examines a human enzyme that unravels these disruptive plaques. Neurodegenerative diseases already affect millions of people in the United States. They tend to strike in middle to later life, and, because the population is starting to live...
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Autism and developmental coordination disorder have similarities but also sharp differences
UTA researchers are recommending in a new study that children diagnosed with autism spectrum disorder should be checked for developmental coordination disorder since the two maladies are linked. In an article published this month in the journal Research in Autism Spectrum Disorders, Priscila Caçola, an assistant professor of kinesiology; UTA librarian Peace Ossom Williamson and Haylie...
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Cognitive Training Using a Novel Memory Game on an iPad in Patients with Amnestic Mild Cognitive Impairment (aMCI)
Abstract Background Cognitive training is effective in patients with mild cognitive impairment but does not typically address the motivational deficits associated with older populations with memory difficulties. Methods We conducted a randomized controlled trial of cognitive training using a novel memory game on an iPad in 42 patients with a diagnosis of amnestic mild cognitive...
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Mitochondrial flash signals long-term memory at neuronal synapse
Why do some memories last a lifetime while others never persist for more than a few minutes? How are short-term memories converted into long-term memories? Recently, a collaborative study led by Dr. BI Guoqiang at University of Science and Technology of China of Chinese Academy of Sciences and Dr. CHENG Heping at Peking University (PKU)...
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Study suggests memories that trigger anxiety, PTSD could be ‘erased’ without affecting normal memory of past events
Different types of memories stored in the same neuron of the marine snail Aplysia can be selectively erased, according to a new study by researchers at Columbia University Medical Center (CUMC) and McGill University and published today in Current Biology. The findings suggest that it may be possible to develop drugs to delete memories that trigger...
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Transcranial stimulation and/or physical therapy improves walking speed in Parkinson’s disease
Noninvasive brain stimulation and physical therapy — alone or in combination — improve some measures of walking ability in patients with Parkinson’s disease (PD), concludes a clinical trial in the American Journal of Physical Medicine & Rehabilitation, the official journal of the Association of Academic Physiatrists. The journal is published by Wolters Kluwer. Transcranial direct current...