Written by Candace Nelson, MS, CN | Reviewed by Katie E. Golden, MD Key takeaways: There are many sources of chronic inflammation in our lifestyle — from stress to diet. And chronic inflammation can put you at risk of long-term health conditions like heart disease and diabetes.Inflammatory foods tend to be processed items that are...
Category: <span>Inflammation</span>
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Vitamin D Not Tied to Clinical, Histologic Features of EoE
Marilynn LarkinVitamin D levels are unlikely to have an impact on the clinical features of eosinophilic esophagitis (EoE) in adults newly diagnosed with the chronic inflammatory disorder, new research suggests. The substantial increase in EoE incidence and the association of low vitamin D levels with increased risk for allergic sensitization prompted the researchers to assess...
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More than just neurons: Scientists create new model for studying human brain inflammation
by Salk Institute Human astrocytes (green) extending processes that wrap around the host blood vessel (magenta). Credit: Salk InstituteThe brain is typically depicted as a complex web of neurons sending and receiving messages. But neurons only make up half of the human brain. The other half—roughly 85 billion cells—are non-neuronal cells called glia. The most common...
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Sinusitis linked to 40% heightened risk of rheumatic disease
by British Medical Journal Credit: Pixabay/CC0 Public DomainThe common inflammatory condition sinusitis is linked to a 40% heightened risk of a subsequent diagnosis of rheumatic disease, particularly in the five to 10 years preceding the start of symptoms, according to research published in the open access journal RMD Open. The risks seem to be greatest for...
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New discovery could lead to better treatment for severe psoriatic arthritis
by Karolinska Institutet Credit: EMBO Molecular Medicine (2024). DOI: 10.1038/s44321-024-00035-zResearchers at Karolinska Institutet have discovered a link between a rare and severe form of psoriatic arthritis and an enzyme that produces oxygen radicals. The study, published in the journal EMBO Molecular Medicine, reveals new ways to slow down or stop the disease progression. Psoriatic arthritis mutilans...
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Researchers identify protein integral to gut health, may lead to treatments for inflammatory bowel disease
by La Trobe University a, b Deletion of BECLIN1, but not ATG7, by addition of 4-hydroxytamoxifen (4-HT) led to significantly smaller intestinal organoids. a, c There was also a significant reduction in the number of “buds” per organoid formed, indicative of reduced stem cell-containing crypt formation. Credit: Communications Biology (2024). DOI: 10.1038/s42003-024-05890-7La Trobe University researchers have...
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Long COVID linked to persistently high levels of inflammatory protein: A potential biomarker and target for treatments
by University of Cambridge Credit: Pixabay/CC0 Public DomainSARS-CoV-2 triggers the production of the antiviral protein IFN-γ, which is associated with fatigue, muscle ache and depression. New research shows that in long COVID patients, IFN-y production persists until symptoms improve, highlighting a potential biomarker and a target for therapies. A University of Cambridge-led study identifies the protein...
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Frozen shoulder research may hold the key to understanding fibrosis resolution
by NDORMS, University of Oxford Tissue sections show frozen shoulder patient tissues exhibit an increased number of cells and blood vessels relative to non-diseased comparator shoulder capsule. Credit: Prof. Stephanie DakinResearchers have identified how cells work to resolve frozen shoulder, opening up potential new targets for treatment and reducing the need for surgery. Frozen shoulder is...
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Faulty DNA disposal system found to cause inflammation
by Salk Institute Endosomes (magenta) collect around mitochondria (blue) after infection with virus HSV-1, which attacks mtDNA (green) and causes its release. Credit: Salk InstituteCells in the human body contain power-generating mitochondria, each with their own mtDNA—a unique set of genetic instructions entirely separate from the cell’s nuclear DNA that mitochondria use to create life-giving energy....
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Points to consider in hyperinflammation
by European Alliance of Associations for Rheumatology (EULAR) Credit: Unsplash/CC0 Public DomainHemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are life-threatening systemic hyperinflammatory syndromes. Systemic hyperinflammation and HLH/MAS can occur in nearly any inflammatory state, but there are certain predisposing conditions and inflammatory triggers. This includes rheumatic diseases, malignancies, metabolic diseases, and genetic immune problems....