Pressure on cells reduces pain signals, but excess cholesterol can interfere, researchers findPeer-Reviewed Publication UF HEALTH IMAGE: A CELL MEMBRANE IS ILLUSTRATED TO SHOW THE SURFACE IN RED. BLUE OBJECTS ARE PROTEINS, INCLUDING ION CHANNELS, WHICH CAN SEND ELECTRICAL IMPULSES INTO CELLS. LIPIDS, OR FATS, ARE IN YELLOW. IN THIS CROSS SECTION, AN ION CHANNEL...
Peer-Reviewed Publication WILEY Capsaicin, derived from hot chili pepper plants, has been used to treat various types of pain, and a high concentration capsaicin patch (HCCP) is approved for the treatment of nerve (or neuropathic) pain. In a real-world study published in Pain Practice that included 97 outpatients in Germany diagnosed primarily with neuropathic back...
by Dennis Thompson Some people might be prone to low back pain because of specific cells contained in their spinal disks, a new study suggests. The research could explain why only certain people develop back pain due to the degeneration of their spinal disks, which are jelly-filled spacers that act as shock absorbers between the...
by University of Pittsburgh Credit: Pixabay/CC0 Public Domain Spinal cord stimulation can elicit sensation in the missing foot and alleviate phantom limb pain in people with lower limb amputations, University of Pittsburgh School of Medicine rehabilitation scientists report today. Pressure sensors on the insole of a prosthetic foot triggered electrical pulses that were then delivered to...
Grant and Award Announcement GRIFFITH UNIVERSITY NYIKINA MANGALA MAN JOHN WATSON AND PROFESSOR RONALD QUINN.view more CREDIT: AUSTRALIAN ACADEMY OF TECHNOLOGICAL SCIENCES & ENGINEERING In 1986, John Watson’s finger was bitten off by a crocodile. A Nyikina Mangala man from the Jarlmadangah Burru Aboriginal Community of the Kimberley, John turned to the bark of the...
by Deb Balzer, Mayo Clinic Credit: Mayo Clinic News NetworkDe Quervain’s tenosynovitis (pronounced da-KWUHR-vanes teena-sine-ah-VITE-us) is a complicated name for a condition that’s been referred to as “mother’s thumb,” “mommy wrist” and “gamer’s thumb”—all associated with repetitive use of the hands and wrist. It is a condition that causes extreme pain in the wrist and...
by Elsevier Diagram of neuroinflammation in endometriosis. Researchers propose that IL-1β activates IL-1 type 1 membrane receptor (IL-1R1) in endometrial stromal cells, predominantly via the c-Jun N-terminal kinase (JNK) pathway, to promote neurotrophin and neurotrophin receptor (NTR) production and signaling, which in turn activate neurogenesis and pain. Parallel pathways promote IL-6 production and IL-1β autoregulation, potentially...
NEW YORK UNIVERSITY IMAGE: AN ARTISTIC REPRESENTATION OF THE INTERACTION BETWEEN THE NAV1.7 SODIUM ION CHANNEL AND COLLAPSIN RESPONSE MEDIATOR PROTEIN 2 (CRMP2). THE RESEARCHERS IDENTIFIED A UNIQUE REGULATORY SEQUENCE IN NAV1.7 THAT IS REQUIRED FOR NAV1.7 FUNCTION. THEY FOUND THAT THIS PEPTIDE DISRUPTED THE INTERACTION WITH CRMP2 AND REDUCED EXCITABILITY IN SENSORY NEURONS. THE...
By UNIVERSITY OF SYDNEY JULY 6, 2023 Analysis of global data spanning over 30 years reveals a growing crisis of low back pain, with projections suggesting 843 million people will suffer from the condition by 2050 due to the increasing population and aging demographics. A review of more than three decades of data reveals an escalating trend...
CELL PRESS IMAGE: THIS DIAGRAM SHOWS HOW NK CELL FUNCTION COULD IN THEORY RESULT IN THE RESOLUTION OF NEUROPATHIC PAIN IN THE CONTEXT OF PERIPHERAL NERVE INJURY BY DIRECTED CYTOTOXICITY AGAINST A NUMBER OF PATHOLOGICAL CELLULAR TARGETS. CREDIT: KIM ET AL./TRENDS IN NEUROSCIENCES In the midst of a global opioid epidemic, a team of scientists...
