by Lori Solomon The U.S. Food and Drug Administration has approved an additional indication for AstraZeneca’s Fasenra (benralizumab) as an add-on maintenance treatment for patients aged 6 to 11 years with severe asthma and an eosinophilic phenotype. This indication was supported by evidence from the Phase III TATE trial, as well as data from additional...
Individual patients with autoimmune diseases can receive tailored medication by computationally treating their so-called digital twins with thousands of medications. This is according to an international study published in Genome Medicine by researchers from Karolinska Institutet. What does your publication show?“It is possible to construct a digital twin of an individual patient’s autoimmune disease. This...
UNIVERSITY OF KENT The emergence of drug-resistant bacteria is a global threat to human health, and the development of new antibiotics from scratch is an extremely expensive and time-consuming process. To address this urgent issue, researchers from the University of Kent’s School of Biosciences have combined computational and microbiology laboratory approaches to identify existing drugs...
TOPLINE:Sodium-glucose cotransporter 2 (SGLT2) inhibitors are associated with a lower risk for sight-threatening retinopathy than other second-line glucose-lowering medications in patients with type 2 diabetes (T2D). METHODOLOGY:Researchers conducted a nationwide cohort study including 3,544,383 patients with newly diagnosed T2D.During the 5-year study period, 159,965 patients were treated with SGLT2 inhibitors, 304,383 received dipeptidyl peptidase-4 (DPP-4)...
by Stanford University Medical Center Metformin 500mg tablets. Credit: public domainAn “anti-hunger” molecule produced after vigorous exercise is responsible for the moderate weight loss caused by the diabetes medication metformin, according to a new study in mice and humans. The molecule, lac-phe, was discovered by Stanford Medicine researchers in 2022. The finding, made jointly by...
by Tina Brown Patients with psoriasis treated with bimekizumab rapidly achieve high levels of clinical and health-related quality-of-life responses that are durable at four years, according to research presented at the annual meeting of the American Academy of Dermatology, held from March 8 to 12 in San Diego. Bruce Strober, M.D., Ph.D., from the Yale...
by University of Surrey A representative scheme for the formulation development. Credit: International Journal of Pharmaceutics (2024). DOI: 10.1016/j.ijpharm.2024.123875Nano micelles of Retinol, a type of vitamin A commonly used in anti-aging beauty products, can also help wounds heal faster by promoting skin tissue regeneration, according to studies conducted by the University of Surrey and Phytoceutical...
by National Institutes of Health Researchers were able to visualize biofilms in teeth treated with dextran-coated gold nanoparticles using photoacoustic imaging. Credit: Journal of Clinical Investigation (2023). DOI: 10.1172/JCI168485If left to their own devices, bacteria on our teeth or wounded skin can encase themselves in a slimy scaffolding, turning into what is called biofilm. These...
Researchers have unveiled a compound that measures up as a potentially powerful anti-coronavirus drug. Stanford University Credit: iStock Although COVID-19 has faded from the headlines, SARS-CoV-2 – the coronavirus behind the pandemic – is still rampantly infecting people around the world. Public health officials fear as the virus continues to evolve, it will eventually hit...
Miriam E. Tucker TOPLINE:European thyroid specialists report willingness to prescribe combination levothyroxine (LT4) + liothyronine (LT3) to patients with hypothyroidism who report persistent symptoms even after normalisation of thyroid-stimulating hormone (TSH) levels. These specialists report LT4+LT3 prescribing despite nearly half attributing patients’ persistent symptoms to nonendocrine causes, and the lack of evidence supporting the efficacy...
