by TranSpread Hypoxia facilitates exosome production and release from BMSCs. (a) Transmission electron microscopy (TEM) revealed the morphology of noBMSC-Exos and hyBMSC-Exos (scale bar: 100 nm). (b) The size distribution of noBMSC-Exos and hyBMSC-Exos was examined using nanoparticle tracking analysis (NTA). (c and d) Western blotting analysis for exosome surface marker proteins, including CD9, CD63,...
Researchers say the genetically engineered stem cells also could pave the way for new regenerative medicine treatments for diseases such as Type 1 diabetes. Deepta Bhattacharya, who is on the University of Arizona Health Sciences Center for Advanced Molecular and Immunological Therapies advisory council, is a professor of immunobiology in the UArizona College of Medicine...
by Liam Connolly, UC Davis Schematic showing putative mechanism of hMSCs mediated immunosuppression in experimental model of Crohn’s disease. Credit: npj Regenerative Medicine (2024). DOI: 10.1038/s41536-024-00347-1A stem cell therapy for Crohn’s disease developed by UC Davis Health researchers has shown promising results in mouse studies. The research, published in npj Regenerative Medicine, showed that human bone...
By Mark Johnson Scientists have discovered a new type of stem cell in the spine that appears crucial to resolving a long-standing mystery: why far more cancer cells spread to the spine than to other bones in the body. When breast, lung and prostate cancers metastasize to multiple bones in the body, three to five...
UCLA researchers have made headway using muscle stem cells to regrow damaged muscle in mice. Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA are one step closer to developing stem cell therapies to regenerate skeletal muscle in humans. Working in mice, the UCLA team discovered how...
by Wiley Credit: CC0 Public DomainCell therapy represents a potential regenerative treatment for osteoarthritis. A recent analysis of all relevant published studies indicates that stem cell transplantation from different sources is effective for treating knee osteoarthritis, the most prevalent chronic joint disease. The review and meta-analysis, which is published in the Journal of Orthopaedic Research,...
by American College of Rheumatology Credit: CC0 Public Domain New research at ACR Convergence 2023, the American College of Rheumatology’s (ACR) annual meeting, shows that patients with refractory juvenile systemic sclerosis improved significantly on nearly all measures for two years following autologous stem cell transplant.Juvenile-onset systemic sclerosis (jSSc), also called scleroderma, is a disfiguring autoimmune disorder...
Seeking strategic partners for continued clinical development of PBCLN-010 with PBCLN-014, a lead investigational therapy comprising human milk sugars and gut bacteria found in nursing infants Business Announcement PROLACTA BIOSCIENCE DUARTE, Calif., Nov. 10, 2023 – In a breakthrough for human milk science, researchers at City of Hope, Los Angeles, have dosed the first patient...
by Brian Katzowitz, Emory University Credit: Pixabay/CC0 Public Domain Characterized by extensive damage to joints and debilitating pain, osteoarthritis (OA) impacts millions of people worldwide and has long posed a substantial clinical and economic burden. In spite of advances in diagnosis, medications, and short-term pain management solutions, the elusive goal of a disease-modifying OA drug has...
by World Journal of Stem Cells Advantages of dental pulp stem cells as alternative stem cells for nerve regeneration. The figure was created with BioRender.com. DPSCs: Dental pulp stem cells. Credit: World Journal of Stem Cells (2023). DOI: 10.4252/wjsc.v15.i10.960 Peripheral nerve injury (PNI) seriously affects people’s quality of life. Stem cell therapy is considered a promising new...
