by University of Delaware NAD+ and NADH concentrations in NEVs and change–change correlations with insulin signaling proteins. (a) Concentration of NAD+ after 6 weeks of oral nicotinamide riboside (NR) supplementation was significantly higher in NEVs when compared to placebo (n = 10, p = 0.0092, paired ttest), while NADH remained relatively unchanged (n = 22, p = 0.215,...
Diana Kwon Illustration by Dalbert B. Vilarino Hundreds of scientists around the world are looking for ways to treat heart attacks. But few started where Hedva Haykin has: in the brain. Haykin, a doctoral student at the Technion — Israel Institute of Technology in Haifa, wants to know whether stimulating a region of the brain...
AMERICAN COLLEGE OF CARDIOLOGY Men who never married were more than twice as likely to die within about five years after a heart failure diagnosis compared with women of any marital status or men who were previously married, according to a study presented at the American College of Cardiology’s Annual Scientific Session Together With the...
MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE IN THE HELMHOLTZ ASSOCIATION IMAGE: INTERACTIONS BETWEEN MACROPHAGES/MICROGLIA AND CEREBRAL VESSELS LEAD TO VASCULAR REGRESSION AND CELL DEATH IN THE BRAIN. IMAGE DEPICTING THE BRAIN OF A ZEBRAFISH WITH MACROPHAGES/MICROGLIA LABELED IN GREEN AND BLOOD VESSELS IN RED. CREDIT: MARIA P. KOTINI, UNIVERSITY OF BASEL Hypertension, or high blood...
EUROPEAN MOLECULAR BIOLOGY LABORATORY IMAGE: A HUMAN INTERACTOME TO PRIORITISE DRUG DISCOVERY CREDIT: KAREN ARNOTT/EMBL-EBI Scientists at Open Targets, EMBL’s European Bioinformatics Institute (EMBL-EBI), and GSK are revealing the shared basis of diseases using a map of interacting human proteins. By helping to understand how biological processes affect human traits and diseases, this work will...
UNIVERSITY OF COPENHAGEN – FACULTY OF SCIENCE IMAGE: FREJA BOHR CREDIT: UNIVERSITY OF COPENHAGEN New research suggests that a large portion of a diabetic’s insulin dose is unlikely to work as expected. University of Copenhagen researchers have discovered that we have miscalculated insulin behavior for many years. The discovery provides a tool for developing better insulin preparations that are...
THE MOUNT SINAI HOSPITAL / MOUNT SINAI SCHOOL OF MEDICINE IMAGE: THE IMAGE SHOWS THAT DURING FASTING A SPECIFIC REGION IN THE BRAIN CONTROLS REDISTRIBUTION OF MONOCYTES IN THE BLOOD WITH CONSEQUENCES ON RESPONSE TO INFECTION UPON REFEEDING. CREDIT: MOUNT SINAI HEALTH SYSTEM Fasting may be detrimental to fighting off infection, and could lead to...
by Columbia University’s Mailman School of Public Health Credit: Pixabay/CC0 Public Domain Using ensemble learning techniques and longitudinal data from a large naturalistic driving study, researchers at Columbia University’s Mailman School of Public Health, Fu Foundation School of Engineering and Applied Science, and Vagelos College of Physicians and Surgeons have developed a novel, interpretable and highly accurate...
by Justin Jackson, Medical Xpress Oral mucosal breaks trigger systemic inflammatory responses.(A) Experimental workflow. (B) Inferred relative bacterial abundances from eight HMP body sites (n = 336). (C) Body site–inferred relative abundances for time points from RA patients with and without periodontal disease, median. (D) Inferred relative oral abundances in blood for one RA donor with and...
by Queensland University of Technology The forest plot demonstrates the odds ratios (ORs) and 95% confidence intervals (CIs) for MR analyses examining the causal effects of glycemic traits on migraine (A) and headache (B). IVW Inverse variance weighted was employed as the primary analysis, GSMR Generalized summary data-based Mendelian Randomisation was used as a sensitivity...
