Month: <span>March 2021</span>

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Researchers hunt for drugs that keep HIV latent
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Researchers hunt for drugs that keep HIV latent

by Ananya Sen,  University of Illinois at Urbana-Champaign Microscopy image of a T-cell population harboring a shortened form of the HIV virus that expresses a green fluorescent protein. Different drug treatments result in the various amounts of cell-to-cell variability in gene expression. Credit: Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign When...

Neutrons reveal unpredicted binding between SARS-CoV-2, hepatitis C antiviral drug
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Neutrons reveal unpredicted binding between SARS-CoV-2, hepatitis C antiviral drug

by  Oak Ridge National Laboratory Neutron scattering experiments show electric charges, shown in red, blue and gray, in the SARS-CoV-2 main protease site where telaprevir binds to the structure. The experiments provide critical data for the design of small-molecule drugs to treat COVID-19. Credit: Jill Hemman and Michelle Lehman/ORNL, U.S. Dept. of Energy Scientists have found...

Arsenal used by parasite to affect cellular defense and enhance leishmaniasis is revealed
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Arsenal used by parasite to affect cellular defense and enhance leishmaniasis is revealed

by Luciana Constantino,  FAPESP Group affiliated with a FAPESP-supported research center showed that the parasite blocks the action of an enzyme using autophagy. Credit: Leishmania (orange) infecting macrophage / Renan V. H. de Carvalho & Dario Zamboni Researchers have succeeded in revealing the arsenal used by protozoans of the genus Leishmania in human cells to make leishmaniasis more severe,...

Rugby study identifies new method to diagnose concussion using saliva
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Rugby study identifies new method to diagnose concussion using saliva

by  University of Birmingham Credit: CC0 Public Domain A University of Birmingham-led study of top-flight UK rugby players—carried out in collaboration with the Rugby Football Union (RFU), Premiership Rugby, and Marker Diagnostics—has identified a method of accurately diagnosing concussion using saliva, paving the way for the first non-invasive clinical test for concussion for use in sport...

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New AI platform can help assess vascular diseases

Mar 23 2021 An international team of scientists from Nanyang Technological University, Singapore (NTU Singapore), Brown University and the Massachusetts Institute of Technology (MIT) has developed an artificial intelligence (AI) platform that could one day be used in a system to assess vascular diseases, which are characterised by the abnormal condition of blood vessels. The...

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Inflammation and pressure-sensing leads to ‘feed-forward’ loop in osteoarthritis

DUKE UNIVERSITY DURHAM, N.C. -An unfortunate biological “feed-forward” loop drives cartilage cells in an arthritic joint to actually contribute to progression of the disease, say researchers at Duke University and Washington University in Saint Louis.  Pain researcher and mechanobiologist Wolfgang Liedtke, a professor of neurology at Duke, partnered with former Duke colleague and cartilage expert Farshid Guilak,...

Scientists reveal regenerative treatment path for diabetic foot ulcers
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Scientists reveal regenerative treatment path for diabetic foot ulcers

SCRIPPS RESEARCH INSTITUTE IMAGE: WATERCOLOR DEPICTION OF THE SKIN’S EPIDERMAL LAYER. IN A NEW STUDY, WOUNDS HEALED QUICKLY AS SKIN CELLS BOUNCED INTRO PRODUCTION MODE AFTER BEING TREATED WITH A NEWLY DISCOVERED REGENERATIVE DRUG COMPOUND. CREDIT: KAYLA NUTSCH OF THE BOLLONG LABORATORY AT SCRIPPS RESEARCH LA JOLLA, CA–A discovery involving multiple teams from across Scripps Research has revealed a powerful new...

Variances in critical protein may guide fate of those infected with SARS CoV-2
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Variances in critical protein may guide fate of those infected with SARS CoV-2

ARIZONA STATE UNIVERSITY IMAGE: Graphic showing the chain of events when a cell is infected with a virus like SARS CoV-2. Within a living cell, proteins derived from pathogens like viruses are cut into fragments in the proteosome. These fragments then migrate through a series of cell structures, including the endoplasmic reticulum and the Golgi...

New anti-cancer therapy: Converting glioma cells into neurons
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New anti-cancer therapy: Converting glioma cells into neurons

GUANGDONG-HONGKONG-MACAU INSTITUTE OF CNS REGENERATION,JINAN UNIVERSITY IMAGE: GLIOMA CELL-CONVERTED NEURONS. RED CELLS ARE GLIOMA CELLS; GREEN CELLS ARE CONVERTED NEW NEURONS. CREDIT: JINAN UNIVERSITY Glioma is a fatal neurological disorder that has limited interventional treatment, despite extensive research over the past several decades. A research team led by Dr. Gong Chen, a former professor at Penn State University and...

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Breakthrough in developing new diagnostic procedure for pulmonary aspergillosis

UNIVERSITY OF EXETER Scientists have developed a pioneering new procedure that will help diagnose a potentially lethal fungal lung disease with greater speed and accuracy, and with less distress to the patient. A team of international scientists, including Professor Chris Thornton from the University of Exeter, has created a new diagnostic procedure for pulmonary aspergillosis....