by University of Helsinki The figure shows immunostaining of lymphoma tissue rich in checkpoint proteins expressing macrophages. Credit: University of Helsinki Approximately 700 people are diagnosed with diffuse large B-cell lymphoma (DLBCL) in Finland each year. It is the most common cancer that originates from lymphocytes, immune system cells. Although the disease is treated with...
The white blood cell TH17 helps the immune system fight infection by promoting inflammation. But it can be too much of a good thing: Excessive inflammation from TH17 overload has been tied to autoimmune disorders, such as inflammatory bowel disease (IBD) and arthritis. Researchers led by Hening Lin, professor of chemistry and chemical biology in the College...
by University of Melbourne Researchers have found a way to stop the rabies virus shutting down the body’s immune defence against it. In doing so they have solved a key scientific puzzle and have laid the foundation for the development of new anti-rabies vaccines. Rabies kills an estimated 60,000 people a year, most of them...
A single injection may have prevented the progression of the human immunodeficiency virus, or HIV, to up to four months, a new study suggests. Researchers in Taiwan reported that the antibodycalled UB-421 was safe and it effectively prevented the virus from destroying the immune system. They reported that a single injection of the antibody is as effective as a daily pill regimen. They published the results of...
Treating precancerous skin lesions prevents full-blown cancer WASHINGTON UNIVERSITY SCHOOL OF MEDICINE A combination of two topical creams already shown to clear precancerous skin lesions from sun-damaged skin also lowers the risk that patients will later develop squamous cell carcinoma of the skin. The study, from Washington University School of Medicine in St. Louis, Massachusetts General Hospital, and...
NEW YORK, NY (February 15, 2019)– Columbia researchers have learned why some glioblastomas–the most common type of brain cancer–respond to immunotherapy. The findings could help identify patients who are most likely to benefit from treatment with immunotherapy drugs and lead to the development of more broadly effective treatments. The study, led by Raul Rabadan, PhD,...
Emerging CAR-T immunotherapies leverage modified versions of patient’s T-cells to target and kill cancer cells. In a new study, published June 28 online in Cell Stem Cell, researchers at University of California San Diego School of Medicine and University of Minnesota report that similarly modified natural killer (NK) cells derived from human induced pluripotent stem cells (iPSCs) also...
UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE A researcher at the University of Miami Miller School of Medicine has found that the use of stimulants, such as methamphetamine, can negatively affect the health of HIV-positive persons even when they are adhering to medical treatment. IMAGE: ADAM CARRICO, PH.D., ASSOCIATE PROFESSOR OF PUBLIC HEALTH SCIENCES AND PSYCHOLOGY...
Cell (stock image). The use of iPSCs to generate tissues would revolutionize transplantation, facilitating the growth of artificial organs, say authors. Houston Methodist researchers have identified an immune pathway that promotes the formation of a cell that can develop into new tissues and organs. In a new study published in the journal Stem Cells, a team...
PITTSBURGH, Feb. 24, 2017 – An in-depth computational analysis of genetic variants implicated in both schizophrenia and rheumatoid arthritis by researchers at the University of Pittsburgh points to eight genes that may explain why susceptibility to one of the disorders could place individuals at lower risk for the other, according to the results of a...
