Jim Kling PHOENIX – New therapies are on the horizon for genetic neuromuscular diseases, and this will raise both hopes for patients and challenges for neurologists. Following successful genetic treatments for ALS, hereditary amyloidosis, and spinal muscular atrophy, therapies for conditions like Charcot-Marie-Tooth (CMT) neuropathy are set to change neurology practice, according to Nicolas Madigan,...
Category: <span>Neurology</span>
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Year-by-Year Blood Pressure Variability From Midlife to Death and Lifetime Dementia Risk
Melina G. H. E. den Brok, MD1,2; Jan Willem van Dalen, PhD1,2; Zachary A. Marcum, PharmD, PhD5; et alWim B. Busschers, PhD3; Tessa van Middelaar, PhD1,2; Nina Hilkens, PhD1; Catharina J. M. Klijn, PhD1; Eric P. Moll van Charante, PhD3,4; Willem A. van Gool, PhD4; Paul K. Crane, MD, MPH6; Eric B. Larson, MD, MPH6,7;...
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Study shows that adaptive immune responses can cause cellular loss in the aging brain
by Ingrid Fadelli, Medical Xpress To characterize aging effect at single cell resolution, Kaya et al. used two different single-cell RNA sequencing (scRNA-seq) methods. For plate-based scRNA-seq (Smart-seq2). They isolated and dissociated grey matter from the frontal cortex and white matter tracts from the corpus callosum as well as the optical tracts and the medial...
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B cells of the immune system discovered in the meninges
UNIVERSITY OF MÜNSTER IMAGE: DIFFERENT TYPES OF WHITE BLOOD CELLS FOUND IN THE OUTER LAYER OF THE MENINGES OF MICE. EXAMINING AROUND 3,000 CELLS, SCIENTISTS ANALYSED WHICH GENES ARE ACTIVE IN EVERY SINGLE CELL AND IDENTIFIED 19 DIFFERENT CELL TYPES. ONE DOT CORRESPONDS TO AN INDIVIDUAL CELL. THE CLOSER THE DOTS ARE TO EACH OTHER,...
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Bedside EEG test can aid prognosis in unresponsive brain injury patients
by Beck Lockwood, University of Birmingham Credit: Pixabay/CC0 Public Domain Assessing the ability of unresponsive patients with severe brain injury to understand what is being said to them could yield important insights into how they might recover, according to new research. A team at the University of Birmingham has shown that responses to speech can be measured...
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Smokers and hypertensive individuals have higher risk of sudden death from brain bleed than previously believed
by University of Helsinki Contrary to the previous data, a Finnish study clarifies that smoking and high blood pressure do not protect from death in patients suffering from subarachnoid hemorrhage, the most lethal stroke subtype. In fact, subarachnoid hemorrhage kills smokers and hypertensive individuals even before they reach hospitals, and therefore, previous studies that did...
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Researchers discover crucial ‘missing link’ between breathing and cardiovascular systems
by Macquarie University A team of researchers from Macquarie University have found a crucial missing link between the parts of the brain that control breathing and those that control the cardiovascular system. The discovery provides clues to how life-threatening conditions such as hypertension develop and may ultimately lead to more effective treatments. The study, conducted...
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Can our thoughts alter our brains?
Brain-computer interfaces have a structural impact on brain substance after one hour of training MAX PLANCK INSTITUTE FOR HUMAN COGNITIVE AND BRAIN SCIENCES The interdisciplinary study examined the influence of two different types of BCI on the brains of test subjects with no prior experience of this technology. The first subgroup was given the task...
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Saffron effectively complements antidepressant medications
by Murdoch University New research has shown that saffron may assist adults with depression when it is taken in conjunction with pharmaceutical antidepressants. Murdoch University researchers Dr. Adrian Lopresti and Professor Peter Drummond, and UWA researcher Professor Sean Hood found greater reductions in depressive symptoms when adults with persistent depression, and currently taking a pharmaceutical antidepressant, complement their depression medication...
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The night gardeners: Immune cells rewire, repair brain while we sleep
UNIVERSITY OF ROCHESTER MEDICAL CENTER Science tells us that a lot of good things happen in our brains while we sleep – learning and memories are consolidated and waste is removed, among other things. New research shows for the first time that important immune cells called microglia – which play an important role in reorganizing...
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