THE UNIVERSITY OF HONG KONG SECRETIN SIGNALING IN THE VENTROMEDIAL HYPOTHALAMUS REGULATES SKELETAL AND METABOLIC HOMEOSTASIS. IMAGE ADAPTED FROM RESPECTIVE PAPER IN NATURE COMMUNICATIONS (2024) view moreCREDIT: THE UNIVERSITY OF HONG KONG A team of researchers from The University of Hong Kong (HKU) has made a significant breakthrough in understanding how energy metabolism and bone...
by Queen Mary, University of London Credit: CC0 Public DomainNew findings reveal that the body undergoes significant, systematic changes across multiple organs during prolonged periods of fasting. The results demonstrate evidence of health benefits beyond weight loss, but also show that any potentially health-altering changes appear to occur only after three days without food. The study,...
by Cactus Communications T cell immunotherapy can be optimized by understanding the metabolism of T cells. This review article summarizes the intricacies of effector and memory T cell metabolic reprogramming and how metabolism can drive T cell exhaustion. Credit: Bo Huang from Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical CollegeWhen foreign antigens...
by Sharita Forrest, University of Illinois at Urbana-Champaign Animal characteristics of conventionally raised C57BL/6J mice that underwent either ovariectomy (OVX) or sham (SHM) surgery and fed either a low-fat (LFD) or a high-fat diet (HFD). Final body weight (a) and energy intake (b) at the end of the 12-week study period as well as body weight...
by City University London Credit: Pixabay from PexelsIn a new study appearing in the Journal of Biophotonics, researchers have found that 670 nanometers (nm) of red light stimulated energy production within mitochondria, leading to increased consumption of glucose. In particular, it led to a 27.7% reduction in blood glucose levels following glucose intake, and it reduced...
by Win Reynolds, Northwestern University Model for BCL6-mediated control of skeletal muscle proteostasis. BCL6-mediated transcriptional regulation controls the expression of atrogenic regulators to establish and maintain skeletal muscle mass. BCL6 directly represses Eif4ebp1 and possibly Mstn, while it directly activates Igf1 and Ar. Loss of Bcl6 in muscle acutely reduces cap-dependent translation and anabolic signaling, resulting...
by Higher Education Press Working model for the role of dAcsl in the regulation of circulating lipoprotein level. Credit: Jie Li, Yue Dong, Tianxing Zhou, He Tian, Xiahe Huang, Yong Q Zhang, Yingchun Wang, Sin Man Lam, Guanghou ShuiInterorgan lipid transport is crucial for organism development and the maintenance of physiological function. Drosophila long-chain acyl-CoA...
by Higher Education Press Workflow to perform snRNA-seq of different WAT depots. The nuclei were derived from subcutaneous (S), epididymal (E), mesenteric (M), peri-nephritic (N), and peri-heart (H) adipose depots, which were pooled from 40 male C57BL/6J mice. Sequencing data went through the quality control process (described in the section of Materials and methods of...
by University of California – San Diego These colored streaks are mitochondrial networks within fat cells. Researchers from UC San Diego discovered that a high-fat diet dismantles mitochondria, resulting in weight gain. Credit: UC San Diego Health SciencesThe number of people with obesity has nearly tripled since 1975, resulting in a worldwide epidemic. While lifestyle factors...
by Eyleen Jorgelina O’Rourke, The Conversation Triacylglycerols, also known as triglycerides, are composed of a glycerol linked to three fatty acids. Credit: Lumen Learning (formerly Boundless) via LibreTexts, CC BY-SAThe journey of aging brings with it an unavoidable reality for many: an increased accumulation of body fat. Though much of society seems mostly focused on the...
