Original story from CNIOAccumulation of “junk proteins”: normal cells (left) and cells subjected to the effect of the toxic arginine-rich protein (right). In the latter, ribosomal proteins (green fluorescent) and the size of nucleoli (red) are increased.Credit: CNIO. Amyotrophic lateral sclerosis (ALS) is a degenerative disease. The neurons responsible for movement begin to die and...
by Impact Journals LLC Correlation between epigenetic clocks and immune cell types. The size of the dots is proportional to the correlation value, being blue a positive correlation and red a negative correlation. Credit: Aging (2024). DOI: 10.18632/aging.205581A new research paper titled “Exploring the effects of dasatinib, quercetin, and fisetin on DNA methylation clocks: a...
by Public Library of Science The study suggests that factors associated with age-related hearing loss differ between males and females. Credit: Mark Paton, Unsplash, CC0 (creativecommons.org/publicdomain/zero/1.0/)Certain factors associated with developing age-related hearing loss differ by sex, including weight, smoking behavior, and hormone exposure, according to a study published in the open-access journal PLOS ONE by Dong...
by Universitat Politècnica de Valènci Monitoring of senolytic intervention with the sulfonic-Cy7Gal probe during natural aging. a Schedule of the senolytic treatment and its monitoring in C57BL/6 mice. 15-m mice received the senolytic drugs D + Q or the vehicle for 5 weeks and, 13 days after senolysis (DAS), the overall β-Gal activity was assessed with sulfonic-Cy7Gal...
by Elana Gotkine In adults 65 years and older, vision impairment is associated with psychosocial outcomes, including symptoms of depression, anxiety, and social isolation, according to a study published online Feb. 22 in JAMA Ophthalmology. Louay Almidani, M.D., from the Johns Hopkins University School of Medicine in Baltimore, and colleagues conducted a cross-sectional analysis of...
A new study has found that mechanical damage to the cell membrane may induce cellular senescence in human cells.Peer-Reviewed Publication OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY (OIST) GRADUATE UNIVERSITY KINTSUGI, THE TRADITIONAL JAPANESE ART OF REPAIRING BROKEN POTTERY BY MENDING CRACKS WITH LACQUER AND GOLD. KINTSUGI VISIBLY INCORPORATES THE HISTORY OF AN OBJECT INTO ITS...
by British Medical Journal Credit: Pixabay/CC0 Public DomainThere seems to be a J-shaped curve between dietary thiamine (vitamin B1) and worsening mental acuity among cognitively healthy older people, suggests research published in the open-access journal General Psychiatry. The sweet spot seems to be a daily intake of 0.68 mg, below which there is relatively little impact....
by Johns Hopkins University School of Medicine Axial CT image with i.v. contrast. Macrocystic adenocarcinoma of the pancreatic head. Credit: public domainOlder people may be at greater risk of developing pancreatic cancer and have poorer prognoses because of age-related changes in cells in the pancreas called fibroblasts, according to research led by investigators from the Johns...
by American College of Cardiology Credit: CC0 Public DomainThe replacement of regular salt with a salt substitute can reduce incidences of hypertension, or high blood pressure, in older adults without increasing their risk of low blood pressure episodes, according to a recent study in the Journal of the American College of Cardiology. People who used a...
Peer-Reviewed Publication MEMORIAL SLOAN KETTERING CANCER CENTER AN IMMUNOFLUORESCENCE IMAGE OF AN AGED MOUSE LIVER. EXPRESSION OF Β-GALACTOSIDASE (WHITE) AND UPAR (YELLOW) IN SENESCENT CELLS SERVE AS TARGET FOR ENGINEERED CAR T CELLS. ELIMINATION OF THESE CELLS IMPROVED AGE-RELATED METABOLIC DYSFUNCTION. CREDIT: MEMORIAL SLOAN KETTERING CANCER CENTER HighlightsLaboratory research led by MSK and Cold Spring...
