(HealthDay)—Long-term use of azathioprine (AZA) is associated with a better disease course in patients with early Crohn’s disease (CD), according to a study published online Sept. 22 in the Journal of Gastroenterology and Hepatology. Yun Qiu, from Sun Yat-sen University in China, and colleagues evaluated the impact of AZA on disease progression in a cohort of 190 patients with...
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Medication that treats parasite infection also has anti-cancer effect
Overview of In vivo pooled library screen of new therapeutic targets for human epithelial ovarian cancer : This is the diagram depicting the overview of in vivo loss-of-function library screens. First, human ovarian cancer cell line was lentivirally transduced with druggable pooled shRNA library or whole-genome CRISPR/Cas9 library, generating large pool of cells with knockdown...
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Stopping aspirin treatment raises cardiovascular risk by over a third
New research published in the journal Circulation suggests that interrupting long-term, low-dose aspirin treatment may increase the likelihood of a second stroke or heart attack. Researchers led by Johan Sundström, a professor of epidemiology at Uppsala University in Sweden, set out to examine the effect of stopping low-dose aspirin treatment on the odds of having a second heart attack or stroke. The American...
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Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
Highlights A modified FOXO4-p53 interfering peptide causes p53 nuclear exclusion in senescent cells This FOXO4 peptide induces targeted apoptosis of senescent cells (TASC) TASC neutralizes murine liver chemotoxicity from doxorubicin treatment TASC restores fitness, hair density, and renal function in fast and naturally aged mice Summary The accumulation of irreparable cellular damage restricts healthspan after...
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Pill made from cellulose that absorbs water to swell up to 100 times its original size ‘can beat obesity’
The pill, called Gelesis100, is made from the vegetable extract cellulose It absorbs water and swells 100 times its original size and helps suppress hunger The treatment is expected to be made available to doctors within two years Doctors last night hailed a new pill that helps obese patients lose up to 10 per cent...
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Rare benign tumors hold the ‘genetic recipe’ to combat diabetes
Rare benign tumors known as insulinomas contain a complicated wiring diagram for regeneration of insulin-producing human beta cells, which may hold the key to diabetes drug development, researchers at the Icahn School of Medicine at Mount Sinai report. The study, titled “Insights into Beta Cell Regeneration for Diabetes via Integration of Molecular Landscapes in...
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Team reveals molecular pathway of weight-controlling hormone
Scientists at NGM Bio have revealed deep insights into the role that a little-understood human hormone plays in regulating body weight. Named Growth and Differentiation Factor 15 (GDF15), this hormone is typically active only when the body experiences acute or prolonged stress, including following exposure to tissue-damaging toxins, such as chemotherapy, or during chronic disease,...