An international team of researchers has shown that a new small-molecule drug can restore brain function and memory in a mouse model of Alzheimer’s disease. The drug works by stopping toxic ion flow in the brain that is known to trigger nerve cell death. Scientists envision that this drug could be used to treat Alzheimer’s...
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Vibrating boot that unblocks arteries in your legs: Device that boosts blood flow could help more than 2.7million Britons
A vibrating plastic boot could help to clear clogged arteries in the leg Called FlowOx, the device has been designed to treat peripheral arterial disease Research shows the boot boosts blood flow to the lower leg by more than 40% A vibrating plastic boot could help to clear clogged arteries in the leg — initial...
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Dibenzoazepine found to be effective against resistant hepatitis C
(Upper panel) Val223 and Phe258 of SPP interacts with the inhibitors for SPP and γ-secretase. (Lower panel) The inhibitor prevents proliferation of protozoa in toxoplasma infected mice. The inhibitor also ameliorates liver steatosis induced. Hepatitis C is caused by a highly infectious virus affecting millions across the globe and can lead to a variety...
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A risk factor for drug-induced skin disease identified
Researchers have identified a type of human leukocyte antigen (HLA) that is associated with the skin disease bullous pemphigoid (BP) in diabetic patients administered with DPP-4 inhibitory drugs. IMAGE: THESE ARE NON-INFLAMMATORY BULLOUS PEMPHIGOIDS (BP) SEEN IN THE TYPE 2 DIABETES PATIENT WHO ARE ADMINISTERED WITH DPP-4 INHIBITOR. DPP-4 inhibitor (DPP-4i) is widely used to...
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Scientist’s accidental exhale leads to improved DNA detector
Greg Madejski held his breath as he looked into the microscope, trying to weld two fingernail-sized chips together: a tiny chip containing a nanofilter on top of another chip with a DNA sensor. It was frustrating work. The chips weren’t making good contact with each other. Madejski gently poked at the chips, then peered over...
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Scientists Create Living 3D Printer Ink Made of Live Bacteria
Rod-shaped bacteria produce cellulose, recognizable as a thread-like structures. Researchers at ETH Zurich in Switzerland have reported in journal Science Advanceson a way of 3D printing materials infused with live bacteria. The development may lead to devices such as implantable blood filters and bacterial factories that produce biomolecules for drugs and other therapies. A myriad of...
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Exclusive: Sexual harassment inside biotech’s biggest hedge fund
Sam Isaly, the founder of biotech’s largest and most powerful hedge fund, has for years perpetuated a toxic culture of sexual harassment, former employees told STAT, routinely subjecting young female assistants to pornography in the workplace, lewd jokes, and pervasive sexist comments. One woman said on several occasions, she glimpsed hardcore pornography playing on the...
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ECOG-ACRIN discovers a simple blood test may predict recurrence of breast cancer
A proof-of-concept study by the ECOG-ACRIN Cancer Research Group measured circulating tumor cells (CTCs) in blood samples from patients cancer-free five years after diagnosis, then associated CTC presence with a later recurrence ECOG-ACRIN CANCER RESEARCH GROUP A simple blood test that detects tumor cells circulating in the blood shows promise as a new way to...
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New Lyme disease tests could offer quicker, more accurate detection
Adult deer tick, Ixodes scapularis. New tests to detect early Lyme disease – which is increasing beyond the summer months -could replace existing tests that often do not clearly identify the infection before health problems occur. In an analysis published on December 7 in Clinical Infectious Diseases, scientists from Rutgers University, Harvard University, Yale University,...
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LDL cholesterol found to be the main modifiable predictor of atherosclerosis in individuals with no risk factor
Cholesterol plaque in a carotid artery, visualized by vascular magnetic resonance imaging. LDL cholesterol (LDL-C), known as ‘bad’ cholesterol, is the underlying reason why many apparently healthy individuals have heart attacks or strokes during middle age despite not having cardiovascular risk factors such as hypertension, smoking, obesity, dyslipidemia or diabetes. Even at levels considered...