UNIVERSITY OF BASELIMAGE: DEVELOPMENT OF CARTILAGE TISSUE FROM MESENCHYMAL STEM/STROMAL CELLS AFTER EIGHT WEEKS IN VIVO: INHIBITION OF THE SIGNALING PATHWAY OF THE PROTEIN BMP LEADS TO THE MAINTENANCE OF STABLE CARTILAGE TISSUE Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes...
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Study shows potential cost savings for early detection and treatment of type 2 diabetes
A large study from Aarhus University, Denmark, showed that for individuals diagnosed with diabetes, screening is associated with a reduction in healthcare costs due to fewer admissions and doctor’s visits and a reduction in prescribed medication Health checks including diabetes risk assessment have been introduced in a number of countries. However, there are few population-based...
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People with Type 2 diabetes who eat breakfast later, more likely to have a higher BMI
Being an “evening person” is linked to higher body mass indices among people with Type 2 diabetes, and having breakfast later in the day seems to be what drives this association, according to a new paper in the journal Diabetic Medicine. Obesity is common among people with Type 2 diabetes. Having an evening preference — waking...
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New study discovers cancer-relevant protein shield
UNIVERSITY OF COPENHAGEN THE FACULTY OF HEALTH AND MEDICAL SCIENCES Researchers from the Novo Nordisk Foundation Center for Protein Research have uncovered a new protein shield that aids in repairing damaged DNA in cells and affects resistance to drugs used for breast cancer treatment. The new study has just been published in the internationally acclaimed...
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New disease model to facilitate development of ALS and MS therapies
Researchers at Karolinska Institutet in Sweden have developed a new disease model for neurodegenerative diseases such as ALS and MS that can be used to develop new immunotherapies. The model is described in a publication in the scientific journal Nature Immunology. All of the body’s organs contain macrophages, which, as part of the immune system, consume...
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Merck pauses Keytruda trials, raising concerns about class
Dive Brief: Merck & Co. disclosed Monday afternoon that it is pausing enrollment in two studies of its checkpoint inhibitor Keytruda (pembrolizumab) due to patient deaths. KEYNOTE-183 and KEYNOTE-185 will not recruit any further patients based on a recommendation from an external data monitoring committee. The two multiple myeloma studies are testing Keytruda in combination and Merck...
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Certain iron supplements may influence the development of colon cancer
Two common iron compounds increase the formation of a known biomarker for cancer, according to a new study of cancer cells from Chalmers University of Technology, Sweden IMAGE: FERRIC CITRATE AND FERRIC EDTA, ARE OFTEN USED IN DIETARY SUPPLEMENTS AND AS A FOOD ADDITIVE RESPECTIVELY, IN WORLDWIDE MARKETS INCLUDING THE USA AND THE EU Two common...
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Dietary lipids play diverse roles in disease
This month’s issue of the Journal of Lipid Research features studies examining how fats in the diet affect health, including whether the ketogenic diet is a reasonable cancer therapy; how the type of unsaturated fats in a mouse’s chow affects inflammation; and how cells respond to nutrient signals. When swapping sugar for ketones doesn’t treat cancer At...
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Lung stem cells repair airways after injury
Newly identified stem cells may hold key to regenerative therapies for lung disease IMAGE: UNIVERSITY OF IOWA RESEARCHERS HAVE IDENTIFIED A NEW POPULATION OF LUNG STEM CELLS THAT APPEAR TO BE IMPORTANT FOR REPAIRING THE AIRWAY FOLLOWING SEVERE INJURY. THE CELLS, WHICH RESIDE CREDIT: CELL STEM CELL The human airway is a system of branching tubes that connects...
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How advanced nanotechnology can improve cancer care
Tel Aviv University, Harvard University researchers discuss the untapped potential of targeted nanocarriers to revolutionize cancer therapy A new Tel Aviv University study addresses the challenges of nanoparticle-based cancer-targeting strategies. It also suggests ways of refocusing the collaborative work of cancer researchers and clinicians to move the field forward from “the bench” to the patients....