The nervous system is a complex network of neurons that coordinate the body by transmission of electrical signals. And just like the power lines that deliver electricity to homes and businesses, the nervous system sometimes needs maintenance. During early development, animals are constantly eliminating unnecessary neuronal material; the nervous systems of insects that undergo metamorphosis...
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An egg a day may keep hair loss at bay, according to dermatologists in Japan
An egg a day may keep hair loss at bay, according to dermatologists in Japan. A series of studies, in which human hair follicles were implanted into mice, found that egg yolk stimulated the growth of new human hair cells. The research, published in the Journal Of Medicinal Food, revealed a compound in egg yolk which, when...
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Vicious circle leads to loss of brain cells in old age
Researchers at the University of Bonn determine how dangerous inflammations in the brain are caused UNIVERSITY OF BONN The so-called CB1 receptor is responsible for the intoxicating effect of cannabis. However, it appears to act also as a kind of “sensor” with which neurons measure and control the activity of certain immune cells in the brain....
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Breakthrough in understanding Warsaw breakage syndrome
Unraveling the action of the DDX11/CHLR1 helicase enzyme in DNA repair TOKYO METROPOLITAN UNIVERSITY Researchers from Tokyo Metropolitan University and the FIRC Institute of Molecular Oncology (IFOM) in Italy have uncovered a previously unknown function of the DDX11 helicase enzyme. Mutations in the gene which codes for DDX11 are known to be implicated in Warsaw Breakage...
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Mutations, drugs drive cancer by blurring growth signals
Novel technique lets researchers control common cancer pathway in the lab with pulses of light, revealing the hidden importance of precise timing in cellular signaling UNIVERSITY OF CALIFORNIA – SAN FRANCISCO Genetic mutations in a form of non-small cell lung cancer (NSCLC) may drive tumor formation by blurring cells’ perception of key growth signals, according to a...
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mRNA polyplexes with post-conjugated GALA peptides efficiently target, transfect and activate antigen presenting cells.
Vaccines based on messenger RNA (mRNA) have emerged as potent systems to elicit CD8+ T cell responses against various cancers and viral infectious diseases. The efficient intracellular delivery of mRNA molecules encoding antigens into the cytosol of antigen-presenting cells (APCs) is still challenging, requiring cell attachment, active uptake and subsequent endosomal escape. Here, we report...
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Comprehensive analysis of body composition and insulin traits associated with intra-pancreatic fat deposition in health and new-onset prediabetes/diabetes after acute pancreatitis
Abstract Current knowledge on biomarkers of intra-pancreatic fat deposition (IFD) is limited. We aimed to analyze comprehensively body composition and insulin traits as biomarkers of IFD in healthy normoglycaemic individuals as well as individuals with new-onset prediabetes and diabetes after acute pancreatitis (NODAP). A total of 29 healthy and 34 NODAP individuals took part in...
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98.6 DEGREES IS A NORMAL BODY TEMPERATURE, RIGHT? NOT QUITE
YOU WAKE UP at 6 am feeling achy and chilled. Unsure if you’re sick or just sleep-deprived, you reach for a thermometer. It beeps at 99°F, so you groan and roll out of bed and get ready for work. Because that’s not a fever. Is it? Yes, it is. Forget everything you know about normal...
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Pharmacists play vital role in improving patient health
Pharmacists serving non-hospitalised patients, such as in general practices and community pharmacies, may achieve improvements in patient health outcomes according to the most comprehensive systematic review of the scientific evidence to date. A team of researchers led by Professor Margaret Watson from the University of Bath, working with Cochrane, NHS Education Scotland, and the Universities...
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Scientists Are Retooling Bacteria to Cure Disease
By manipulating DNA, researchers are trying to create microbes that, once ingested, work to treat a rare genetic condition — a milestone in synthetic biology. A newborn is tested for PKU, a rare inherited blood disorder, at a hospital in California.CreditCreditSpencer Grant/Science Source In a study carried out over the summer, a group of volunteers...