Scientists have developed a new way to deliver anti-parasitic medicines more efficiently. An international team, led by Professor Francisco Goycoolea from the University of Leeds and Dr Claudio Salomon from the Universidad Nacional de Rosario, Argentina, and in collaboration with colleagues at the University of Münster, Germany, have developed a novel pharmaceutical formulation to administer...
Year: <span>2018</span>
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Driving with dementia—New guidance for doctors
New guidance on when people living with dementia should stop driving has been published to support doctors and other health care professionals. ‘Driving with Dementia or Mild Cognitive Impairment’ helps medical teams with the appropriate assessment and management of patients. Researchers from Newcastle University, supported by the National Institute for Health Research (NIHR) Newcastle Biomedical...
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Your brain on imagination: It’s a lot like reality, study shows
Imagine a barking dog, a furry spider or another perceived threat and your brain and body respond much like they would if you experienced the real thing. Imagine it repeatedly in a safe environment and soon your phobia–and your brain’s response to it–subsides. That’s the takeaway of a new brain imaging study led by University...
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Some brain tumors may respond to Immunotherapy, new study suggests
Immunotherapy has proved effective in treating a number of cancers, but brain tumors have remained stubbornly resistant. Now, a new study suggests that a slow-growing brain tumor arising in patients affected by neurofibromatosis type 1 (NF1) may be vulnerable to Immunotherapy, which gives the immune system a boost in fighting cancer. The findings, made by an international consortium led by researchers at Columbia University Vagelos College of...
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Toward an improved treatment of anxiety disorders
Traumatic experiences can become deeply entrenched in a person’s memory. How can fears following a traumatic event be reduced in the long term and prevented from becoming a permanent stress-related disorder? Researchers at the Mainz University Medical Center have recently shed new light on these questions. The key to their approach lies in firmly anchoring...
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Taking uncertainty out of cancer prognosis
An analysis of breast cancer patient gene reveals that copy number alterations (CNAs) within cancer-causing genes is more likely to accurately indicate the severity of the disease (shown) than simply measuring how many of those genes. A cancer diagnosis tells you that you have cancer, but how that cancer will progress is a terrifying uncertainty...
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Successful anti-PD-1 therapy requires interaction between CD8+ T cells and dendritic cells
A team led by a Massachusetts General Hospital (MGH) investigator has found that successful cancer immunotherapy targeting the PD-1 molecule requires interaction between cytotoxic CD8+ T cells, which have been considered the primary therapeutic target, and dendritic cells, critical activators of T cell response. The report that will be appearing in the journal Immunity and...
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Researchers discover unique immune cell likely drives chronic inflammation
For the first time, researchers have identified that an immune cell subset called gamma delta T cells that may be causing and/or perpetuating the systemic inflammation found in normal aging in the general geriatric population and in HIV-infected people who are responding well to drugs (anti-retrovirals). Even with effective viral control, HIV-infected individuals are at...
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Electric fields: cancer killers?
Pulsing cells with electric fields can force calcium diffusion into cells. Researchers have now optimized this technique in an attempt to kill cancer cells and leave healthy cells intact. Researchers from the Bioelectrics Department of Kumamoto University (Japan) have identified the optimal pulsed electric field (PEF) conditions for the maximum calcium cell membrane permeability. There...
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Killing the liver-stage malaria parasite with baculovirus: a drug discovery approach
Researchers at Kanazawa University have discovered that an insect virus (a baculovirus) can completely eliminate liver-stage malaria parasites in mice, thus offering hope for safer and more effective treatments for the disease than existing drugs KANAZAWA UNIVERSITY Kanazawa, Japan – Currently, few antimalarial treatments exist that effectively kill liver-stage malaria parasites, which can lay dormant...