Posted Today A research team headed by scientists at University of California San Diego School of Medicine and the Ludwig Institute for Cancer Research at UC San Diego has identified an enzyme involved in remodeling the plasma membrane of multiple cancer cell types that is critical to both survival of tumors and their uncontrolled growth. The...
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Turbo chip for drug development
by Karlsruhe Institute of Technology In spite of increasing demand, the number of newly developed drugs decreased continuously in the past decades. The search for new active substances, their production, characterization, and screening for biological effectiveness are very complex and costly. One of the reasons is that all three steps have been carried out separately so...
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Immune cells reprogrammed to kill HIV-infected T cells
There exists a group of HIV-positive people who have the rare ability to naturally control the HIV infection. Now, after years of research, a team of scientists from the Institut Pasteur in Paris, has successfully reprogrammed cells that lack this ability, giving them the same incredible, antiviral potency. Less than one percent of people living...
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Can magnetic stem cells improve cartilage repair?
by Mary Ann Liebert, Inc Cells equipped with super paramagnetic iron oxide nanoparticles (SPIOs) can be directed to a specific location by an external magnetic field, which is beneficial for tissue repair. Researchers have now taken the important step of evaluating the safety and efficacy of magnetically labeled mesenchymal stem cells (MSCs) for use in repairing...
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Genetic study reveals metabolic origins of anorexia
by King’s College London A global study, led by researchers at King’s College London and University of North Carolina at Chapel Hill, suggests that anorexia nervosa is at least partly a metabolic disorder, and not purely psychiatric as previously thought. The research was published in Nature Genetics today. The large-scale genome-wide association study, undertaken by over 100 academics worldwide, identified eight genetic variants...
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Study dispels myth of exercise damage in the treatment of osteoarthritis of the knee
by Alison Ramsay, University of Aberdeen A study by scientists has discovered that therapeutic exercise does not harm articular cartilage of the knee in people with osteoarthritis, a leading cause of disability worldwide associated with pain, impaired mobility and quality of life. It may, in fact, benefit articular cartilage. Despite physical exercise (including therapeutic exercise) being one of the three key osteoarthritis treatment...
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Lipid Nanoparticles Deliver CRISPR/Cas9 into Organs with High Efficiency
CONN HASTINGS GENETICS The CRISPR/Cas9 system is currently being investigated as a way to treat a variety of diseases with a genetic basis, including Duchenne muscular dystrophy, Huntington’s, and sickle cell disease. While the system has significant promise, there are some issues that need to be resolved before it can be used clinically. CRISPR/Cas9 is a large complex, and...
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New study discovers genetic changes linked to leukaemia in children with Down’s syndrome
Posted Today This news or article is intended for readers with certain scientific or professional knowledge in the field. Researchers at the University of Oxford, in collaboration with colleagues from Hannover Medical School and Martin-Luther-University Halle-Wittenberg, have discovered the specific gene mutations that are required for the development of leukaemia in children with Down’s syndrome. Children...
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Link between paid employment and slower age-related memory decline
by Alzheimer’s Research UK Over the past century, patterns of employment, marriage and parenthood have changed drastically for women across the Western World. In a study presented today at the Alzheimer’s Association Internal Conference 2019, researchers have explored how differences in life experiences affect later life memory decline. A team of researchers from the University of California looked at...
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Parkinson’s disease study identifies possible new treatment target
by Ziba Kashef, Yale University Treatments for Parkinson’s disease have most recently focused on increasing dopamine, a chemical messenger in the brain that affects reward-based behaviors and motivation, as well as movement. A new study by Yale researchers challenges long-held assumptions about dopamine’s sole role in this disorder. In people with Parkinson’s disease, nerve cells that produce dopamine slowly die. The loss...