Neuroscientific approach may help reconcile self-reported emotions and their neural underpinnings SOCIETY FOR NEUROSCIENCE Researchers applied a machine learning technique that could potentially translate patterns of activity in fear-processing brain regions into scores on questionnaires used to assess a patient’s fear of pain. This neuroscientific approach, reported in eNeuro, may help reconcile self-reported emotions and their...
Year: <span>2019</span>
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Targeting kinetoplastid and apicomplexan thymidylate biosynthesis as antiprotozoal strategy
This article by Dr. Dolores Gonzalez Pacanowska et al. is published in Current Medicinal Chemistry, 2018 BENTHAM SCIENCE PUBLISHERS Kinetoplastid and apicomplexan parasites include protozoans which are responsible for human diseases, and cause a serious impact on human health and the socioeconomic growth of developing countries. Chemotherapy is the main option to control these pathogenic...
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GenMark Fungal Blood Culture Test Clears FDA
NEW YORK (GenomeWeb) – GenMark Diagnostics announced today it has received 510(k) clearance from the US Food and Drug Administration for a molecular diagnostic panel assay to detect fungal pathogens from blood cultures of patients with suspected blood stream infections. The test is called the ePlex Blood Culture Identification Fungal Pathogen (BCID-FP) Panel. It runs...
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Combo of existing drugs fights bowel cancer and reduces side effects
The combination of a common cancer drug and another cancer medication is more effective than some standalone drugs in stopping the progression of colorectal cancer. It also reduces unpleasant side effects. Dr. Richard Goldberg, director of the West Virginia University Cancer Institute in Morgantown, wanted to look for new ways to slow the progression of colorectal...
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Exome sequencing provides genetic diagnosis for some with CKD
Emily E. Groopman, from Columbia University in New York City, and colleagues conducted exome sequencing and diagnostic analysis for 3,315 patients with chronic kidney disease (two cohorts). A total of 3,037 patients were over age 21 years and 35.6 percent were self-identified as non-European ancestry. (HealthDay)—Genes are responsible for approximately one in 10 cases of chronic kidney...
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Experts treat severe, disfiguring sarcoidosis with novel therapy
An all-Yale team of researchers successfully treated a patient with disfiguring sarcoidosis, a chronic disease that can affect multiple organs, with a drug approved for rheumatoid arthritis. Successful treatment of two other patients with similarly severe disease suggests an effective treatment for an incurable, sometimes life-threatening illness is within reach, the scientists said. Credit: CC0...
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Study identifies genetic mutation responsible for tuberculosis vulnerability
If you live in the United States, you are unlikely to come into contact with the microbe that causes tuberculosis. Your odds of encountering the microbe are so low, in fact, that risk factors for the disease can easily go unnoticed: If you happened to carry a gene that predisposed you to tuberculosis, you likely...
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Synaptic protein regulates anxiety behaviour
Anxiety disorders are severe mental disorders in which patients suffer from intense fears and anxiety or from sudden, inexplicable panic attacks. In extreme cases, the affected individuals barely leave their homes, which can have serious consequences for their relationships with family and friends as well as for their professional lives. Scientists at the Max Planck...
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Human blood cells can be directly reprogrammed into neural stem cells
Scientists from the German Cancer Research Center (DKFZ) and the stem cell institute HI-STEM in Heidelberg have succeeded for the first time in directly reprogramming human blood cells into a previously unknown type of neural stem cell. These induced stem cells are similar to those that occur during the early embryonic development of the central...
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A tilt of the head facilitates social engagement, researchers say
Every time we look at a face, we take in a flood of information effortlessly: age, gender, race, expression, the direction of our subject’s gaze, perhaps even their mood. Faces draw us in and help us navigate relationships and the world around us. How the brain does this is a mystery. Understanding how facial recognition works...