The 2020 Canada Gairdner International Award has been awarded to Elaine Fuchs for her discovery of the role of adult skin stem cells in homeostasis, wound repair, inflammation, and cancer. These insights have established a foundation for basic knowledge on how adult stem cells form, maintain, and repair tissues and have provided the groundwork for...
A new mechanism triggering cell death and inflammation: A left turn that kills
UNIVERSITY OF COLOGNE Z-form nucleic acids are double-stranded DNA and RNA molecules with an unusual left-handed double helix structure, as opposed to the classical right-handed Watson-Crick double helix. Z-nucleic acids were discovered more than 40 years ago, but their biological function has remained poorly understood. The group of Professor Manolis Pasparakis at the CECAD Cluster...
Less expensive, more effective pneumonia vaccines are tested in humans
Developed by researchers at the Butantan Institute (Brazil) and Boston Children’s Hospital, part of the Harvard Medical School (USA), the innovation is capable of providing protection against all serotypes of the bacterium Streptococcus pneumoniae. FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO A novel vaccine against pneumonia that is less expensive and more...
Researchers gain new insights into pain signaling in the brain
UNIVERSITY OF COPENHAGEN THE FACULTY OF HEALTH AND MEDICAL SCIENCES Fast communication between our brain cells – or neurotransmission as it is called – is hugely important for our brain to work properly. Some of the messengers involved in this form of communication are neuropeptides, which are chemicals produced in the brain. Some of these...
Novel cell-based cancer immunotherapy shows promise in early studies
A new cell therapy is effective in human and mouse models and reveals the potential of using mouse tumour models in evaluating the effectiveness, safety and mechanisms of this type of treatment Scientists have developed a new immunotherapy that eradicates solid tumours in mice without adverse side effects, according to a new study published today...
Discovery of new biomarker in blood could lead to early test for Alzheimer’s disease
UNIVERSITY OF CALIFORNIA – SAN DIEGO Researchers at the University of California San Diego discovered that high blood levels of RNA produced by the PHGDH gene could serve as a biomarker for early detection of Alzheimer’s disease. The work could lead to the development of a blood test to identify individuals who will develop the...
Wearable device lets patients with type 2 diabetes safely use affordable insulin option
THE ENDOCRINE SOCIETY WASHINGTON–Adults with type 2 diabetes requiring insulin therapy can safely achieve good blood sugar control using regular human insulin (RHI) in a wearable, patch-like insulin delivery device called V-Go®, a new study finds. Results of the randomized controlled study–which was accepted for presentation at ENDO 2020, the Endocrine Society’s annual meeting, and...
Researchers offer hope for an oral, noninjectable treatment of acromegaly
THE ENDOCRINE SOCIETY WASHINGTON– Adults who need medical maintenance treatment of the growth hormone disorder acromegaly respond well to an investigational oral form of the drug octreotide, investigators of the Chiasma OPTIMAL study reported. Results of the phase 3 randomized controlled clinical trial were accepted for presentation at ENDO 2020, the Endocrine Society’s annual meeting,...
Bariatric surgery may be effective treatment for non-alcoholic fatty liver disease
THE ENDOCRINE SOCIETY WASHINGTON–Bariatric surgery may be an effective treatment for non-alcoholic fatty liver disease (NAFLD), suggests a new study accepted for presentation at ENDO 2020, the Endocrine Society’s annual meeting, and publication in the Journal of the Endocrine Society. The study compared three types of bariatric, or weight loss, surgery: gastric sleeve, gastric band...
Magnetic stimulation may help common problem of fecal incontinence
by Medical College of Georgia at Augusta University A low-cost, noninvasive treatment that uses the power of the magnet to stimulate and heal nerves key to bowel control is under study for the disabling and common problem of stool leakage, or fecal incontinence. The technique, translumbosacral neuromodulation therapy, or TNT, has shown early promise in...