Scientists have identified the binding pocket for molecules that can stabilize a key braking mechanism in cancer — opening the door to the development of drugs that target it. A team of scientists led by the University of Michigan Rogel Cancer Center and Case Comprehensive Cancer Center has identified the binding site where drug compounds...
by Lori Dajose Viruses are nature’s Trojan horses: They gain entrance to cells, smuggle in their genetic material, and use the cell’s own machinery to replicate. For decades, scientists have studied how to minimize their deleterious effects and even repurpose these invaders to deliver not their own viral genome, but therapeutics for treating disease and...
In the 2020 April 21 issue of Journal of Hepatology, a research group from the Department of Hepatology in Osaka City University Graduate School of Medicine, Japan reported that a new insight into the pathophysiology of human nonalcoholic steatohepatitis (NASH) with fibrosis and suggested a possibility of the new therapy using cytoglobin (CYGB) inducer for...
By: LUNGHAMMER – TU GRAZ Whether activating or silencing genes, breaking down defective cells or building new tissue, our body is constantly working to repair itself, even in cases of illness. To fight a disease, our body sends out signals, often long before we ourselves notice the disease. Such signals are, for example, DNA molecules...
B: UNIVERSITY OF BRISTOL A new study led by the University of Bristol has shown a common eye condition, glaucoma, could be successfully treated with a single injection using gene therapy, which would improve treatment options, effectiveness and quality of life for many patients. Glaucoma affects over 64 million people worldwide and is a leading...
BY : MARY ANN LIEBERT, INC., PUBLISHERS New Rochelle, NY, April 21, 2020–Two new case studies highlight the use of tele-diabetes to manage new-onset type 1 diabetes in an adult and an infant during the COVID-19 pandemic. The article describing these experiences and providing perspectives on the future application of tele-diabetes is published in Diabetes...
A team of researchers at University of California San Diego School of Medicine and Moores Cancer Center used CRISPR technology to identify key regulators of aggressive chronic myeloid leukemia, a type of cancer that remains difficult to treat and is marked by frequent relapse. “We used CRISPR technology to carry out a genome-wide screen in...
by Bob Marcotte, University of Rochester Medical Center “Is your pain tolerable?” A new study out today from the JAMA Network found that this simple question, used in conjunction with the traditional 0-10 rating scale posed to patients, could help doctors better understand whether treatments for pain, including opioid medications, are actually necessary. “Because of...
by Bob Yirka , Medical Xpress team of researchers from several institutions in the U.S. has found a link between the onset of chronic back pain and changes to the nucleus accumbens in the brain. In their paper published in Proceedings of the National Academy of Sciences, the group describes their study of volunteers with...
by Queen Mary, University of London Mice with high levels of this protein were also found to exhibit behaviours that are characteristic of anxiety and stress, such as digging and excessive grooming. When the researchers treated the mice with an antibody that neutralised Imood, the animals’ anxiety levels reduced. The findings have led the researchers...
