by Yale University Yale researchers have discovered a “jamming signal” that blocks a powerful immune system stimulant called interleukin-18 (IL-18) from reaching tumors, including in cancers that are resistant to conventional immunotherapy treatments, they report June 24 in the journal Nature. The research team created a version of IL-18 that could not be jammed and...
by RIKEN A new study by researchers at the RIKEN Center for Integrative Medical Science in Japan reports differences in blood cell mutations between Japanese and European populations. The study found that these pre-clinical mutations were strongly associated with different types of cancers and can explain why Europeans have higher rates of chronic lymphocytic leukemia,...
by University of Cincinnati UC researchers have found a potential new combination therapy for breast cancer that would integrate use of the body’s immune system with targeted treatment for a particular protein that advances cancer. The study, published in the journal Cancer Research, a journal of the American Association for Cancer Research, provides data that...
by National Institute for Health Research BioResource A research program pioneering the use of whole-genome sequencing in the NHS has diagnosed hundreds of patients and discovered new genetic causes of disease. Whole genome sequencing is the technology used by the 100,000 Genomes Project, a service set up by the government which aims to introduce routine...
by Sanford Burnham Prebys Medical Discovery Institute Scientists at Sanford Burnham Prebys Medical Discovery Institute and Radboud University Medical Center in the Netherlands have identified mutations in a gene called CNOT1 that affect brain development and impair memory and learning. The study is the first to link neurodevelopmental delays with CNOT1, suggesting that drugs that...
by University of Zurich Neuroscientists of the University of Zurich shed a new light on the mechanisms responsible for familial migraine: They show that a genetic dysfunction in specific brain cells of the cingulate cortex area strongly influences head pain occurrence. Migraine is one of the most disabling disorders, affecting one in seven people and...
GERMAN CANCER RESEARCH CENTER (DEUTSCHES KREBSFORSCHUNGSZENTRUM, DKFZ) Chimeric antigen receptor (CAR) T cell therapy is a new and in some cases highly effective form of immunotherapy to treat certain types of cancer of the blood and lymph system. This promising treatment comes at a cost, however: The manufacturers charge up to EUR 320,000 for the...
Innovative wireless split-ring resonator concentrates microwaves into a hot-spot for ultrasound emission SPIE–INTERNATIONAL SOCIETY FOR OPTICS AND PHOTONICS THERMOACOUSTIC IMAGING OF ULTRASOUND WAVE GENERATION FROM THE SPLIT RING RESONATOR, FROM LAN ET AL. 2020, FIGURE 3 (DOI 10.1117/1.AP.2.3.036006) view more CREDIT: SPIE Ultrasound imaging is one of the workhorses in a modern hospital. It hits...
by Sanford Burnham Prebys Medical Discovery Institute Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a next-generation drug called Ciapavir (SBI-0953294) that is effective at reactivating dormant human immunodeficiency virus (HIV). The research, published in Cell Reports Medicine, aims to create a functional HIV cure by activating and then eliminating all pockets of...
by NYU Langone Health After a brain injury, cells that normally nourish nerves may actually kill them instead, a new study in rodents finds. This “reactive” phenomenon may be the driving factor behind neurodegenerative diseases like glaucoma, a leading cause of blindness. Led by researchers at NYU Grossman School of Medicine, the study examined what...
