by Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.) Confocal microscopy projection image of a mouse heart in which a multispectral genetic mosaic was induced in coronary vessels. This novel genetic and imaging technology was used to label and fate map individual coronary endothelial cells containing distinct genetic mutations. These mutations either impair or promote...
Amazon’s new health band is the most invasive tech we’ve ever tested
Geoffrey A. Fowler and Heather Kelly, The Washington Post Photo: Amazon.IMAGE 1 OF 3The optional body feature in the Halo app asks you to take four photos of your body in underwear or skintight clothes, and the generates an estimate of your body fat composition and a 3-D model of your body. Amazon has a new health-tracking bracelet...
New cancer immunotherapy shows great promise in early research
by Purdue University Timothy L. Ratliff, the Robert Wallace Miller Director of the Purdue University Center for Cancer Research, is part of a team of scientists who have developed the first universal cancer treatment that targets non-malignant cells in tumors. Credit: Purdue University A new approach to cancer immunotherapy has the potential to be a universal treatment...
Inhaled vaccine induces fast, strong immune response in mice and non-human primates
by Cell Press Credit: CC0 Public Domain Researchers demonstrate in a proof-of-concept study that a phage-based inhalation delivery system for vaccines generates potent antibody responses in mice and non-human primates, without causing lung damage. The findings suggest that a safe and effective lung delivery system could one day be used for vaccines and therapeutics against respiratory diseases....
Gene discovery could help prevent heart attacks
by University of Virginia Credit: CC0 Public Domain Researchers at the University of Virginia have shed light on how our genes affect our risk for coronary artery disease, the most common form of heart disease. In addition to identifying gene variants that influence risk, they found that one gene in particular appears to have a protective effect....
Scientists discover a key genetic driver of lymphomas
by Weill Cornell Medical College Histone H1 (fragment shown here in gray) binds and condenses DNA to repress gene activity. Mutations in histone H1 (highlighted in red) have been identified at high frequency in many hematological malignancies. Credit: Weill Cornell Medical College Mutations in proteins called histone H1, which help package DNA in chromosomes, are a...
Toxin provides clues to long-term effects of diarrhea caused by E. coli
by Tamara Bhandari, Washington University School of Medicine Toxin-producing E. coli bacteria (green) attach to human intestinal cells expressing the protein CEACAM6 (red). A study from researchers at Washington University School of Medicine in St. Louis has found that a toxin produced by E. coli changes intestinal cells to benefit itself, an ability that could provide a clue...
NUS researchers finds best combination of available therapies against COVID-19
NATIONAL UNIVERSITY OF SINGAPORE IMAGE: (FROM LEFT) PROFESSOR DEAN HO, ASSOCIATE PROFESSOR EDWARD CHOW, AND DR AGATA BLASIAK WORKED WITH THEIR COLLABORATORS TO DERIVE AN OPTIMAL COMBINATION OF AVAILABLE THERAPIES AGAINST SARS-COV-2 USING THE IDENTIF.AI PLATFORM CREDIT: NATIONAL UNIVERSITY OF SINGAPORE A team of researchers from the National University of Singapore (NUS) has utilised a ground-breaking artificial...
Melatonin: finally, a supplement that actually boosts memory
TOKYO MEDICAL AND DENTAL UNIVERSITY IMAGE: THREE 1-MINUTE TRAINING TRIALS (A) REVEALED AGE-ASSOCIATED OBJECT MEMORY DECLINE IN MIDDLE-AGED AND OLD MICE AT 1 DAY POST-TRAINING (B). SYSTEMIC AMK (1 MG/KG) ADMINISTERED AFTER A SINGLE 1-MINUTE TRAINING TRIAL ENHANCED OBJECT MEMORY AT 1 AND 4 DAYS POST-TRAINING IN ALL AGE GROUPS (D-F). CREDIT: DEPARTMENT OF BIOLOGY,TMDU...
Hematoxylin as a killer of CALR mutant cancer cells
CEMM RESEARCH CENTER FOR MOLECULAR MEDICINE OF THE AUSTRIAN ACADEMY OF SCIENCES IMAGE: FIRST AUTHOR RUOCHEN JIA AND LAST AUTHOR ROBERT KRALOVICS. CREDIT: FIRST AUTHOR RUOCHEN JIA AND LAST AUTHOR ROBERT KRALOVICS. Patients with myeloproliferative neoplasm (MPN), a group of malignant diseases of the bone marrow, often have a carcinogenic mutated form of the calreticulin gene (CALR)....