An investigational anti-HIV antibody delivered intravenously once every eight weeks safely and effectively prevented the acquisition of HIV strains sensitive to that antibody, but did not significantly reduce overall HIV acquisition after 80 weeks among participants in two multinational clinical trials. Known as the Antibody-Mediated Prevention (AMP) Studies, the Phase 2b trials are sponsored and...
How cells develop and the diseases that arise when development goes wrong have been a decades-long research focus in the laboratory of Distinguished Professor of Biology Ellen Rothenberg. In particular, the lab studies the development of immune cells known as T cells, which act as “intelligence agents”—they circulate throughout the body, detect threats, and determine what kind of...
A chemical probe molecule—a “first-gen” molecule that can be used for drug development—that targets a host cell’s protein quality control pathways can dramatically reduce infection by Dengue and Zika viruses. The research led by Lars Plate, assistant professor of chemistry and biological sciences, is a significant step toward host-directed antiviral therapeutics that act on host cells and not...
UNIVERSITY OF MONTREAL HOSPITAL RESEARCH CENTRE (CRCHUM) Montreal, January 27, 2021 – Taking cannabidiol, a chemical in the cannabis sativa plant, isn’t an effective way to reduce your dependence on cocaine, researchers at the CHUM Research Centre find. In North America, close to 5.5 million people use cocaine regularly, and nearly one in five becomes addicted, developing cocaine use disorder, for...
by Patrick Lejtenyi, Concordia University Chiara Gamberi (left) and Cassandra Millet-Boureima: “I hope there will be more research on the drugs we tested and that we get more results that will help the polycystic kidney disease community.” Credit: Concordia University A hormone commonly associated with sleep-wake regulation has been found to reduce cysts in fruit flies, according to...
by McGill University Credit: CC0 Public Domain Researchers from McGill University have discovered, for the first time, one of the possible mechanisms that contributes to the ability of lysergic acid diethylamide (LSD) to increase social interaction. The findings, which could help unlock potential therapeutic applications in treating certain psychiatric diseases, including anxiety and alcohol use disorders, are...
by Boston University School of Medicine Credit: CC0 Public Domain When severely or chronically injured, the liver loses its ability to regenerate. A new study led by researchers at the Center for Regenerative Medicine at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) now describes a safe new potential therapeutic tool for the recovery of...
by Inselspital, Bern University Hospital Credit: CC0 Public Domain A research team at Inselspital, Bern University Hospital and the University of Bern has identified and tested the use of an agent that can effectively inhibit the proliferation of leukemia stem cells. Metoclopramide (MPR), used as an anti-emetic medication, interrupts the unique CD93 signaling pathway that only leukemia...
by Karolinska Institutet Model highlighting epigenetic chromatin remodeling at the Ccl2 locus, encoding the pro-inflammatory chemokine CCL2 (MCP-1), a potential therapeutic target. Credit: Zhiqiang Huang and Rongrong Fan How do cis-regulatory genome elements regulate gene expression, what are the critical components involved, and can we therapeutically target them? By investigating how corepressors modulate enhancers and silencers...
By Pete Farley Plitidepsin was 27.5-fold more potent against SARS-CoV-2 than remdesivir, a drug that received FDA emergency use authorization in 2020 for the treatment of COVID-19, according to new research. Image by NIH Scientists at UC San Francisco’s Quantitative Bioscience Institute (QBI) and the Icahn School of Medicine at Mt. Sinai (ISMMS) in New York have shown that plitidepsin...
